{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that miR-3195 expression is significantly altered in various pathological contexts. In patients with traumatic brain injury (TBI), plasma levels of miR-3195 are notably elevated in severe cases compared with mild and moderate forms, suggesting its potential use as a diagnostic biomarker for distinguishing TBI severity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nIn the field of dental development, miR-3195 has been identified as one of the key regulators in ameloblast differentiation. This finding, emerging from investigations into amelogenesis imperfecta, implicates miR-3195 in the modulation of genes critical for extracellular matrix formation and proper enamel development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n\nIn oncology, the functions of miR-3195 appear context-dependent. Although its aberrant expression has been reported in osteosarcoma—with its specific biological role remaining to be fully elucidated"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "—more defined activities have been observed in non‐small cell lung cancer (NSCLC). In NSCLC, miR-3195 is downregulated, and restoration of its levels inhibits cell proliferation and migration, promotes apoptosis, and reduces cisplatin resistance through targeting of PFKFB4, thereby highlighting its potential tumor‐suppressive role and contribution to overcoming chemotherapy resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaojing Qin, Lingzhi Li, Qi Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profile of plasma microRNAs and their roles in diagnosis of mild to severe traumatic brain injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0204051"}], "href": "https://doi.org/10.1371/journal.pone.0204051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30226895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30226895"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hiroki Yoshioka, Yin-Ying Wang, Akiko Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miR-1306-5p, miR-3195, and miR-3914 Inhibits Ameloblast Differentiation through Suppression of Genes Associated with Human Amelogenesis Imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22042202"}], "href": "https://doi.org/10.3390/ijms22042202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33672174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33672174"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianwei Liang, Dandan Bao, Zhan Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3195 suppresses the malignant progression of osteosarcoma cells via targeting SOX4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Orthop Surg Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13018-023-04321-3"}], "href": "https://doi.org/10.1186/s13018-023-04321-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37904207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37904207"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rong Chen, Xiaoyan Gao, Yahui Shen "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3195 inhibits non-small cell lung cancer malignant behaviors along with cisplatin resistance through targeting PFKFB4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14715/cmb/2024.70.7.10"}], "href": "https://doi.org/10.14715/cmb/2024.70.7.10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39097893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39097893"}]}]}]}