| HGNC Family | Non-coding RNAs |
| Name | microRNA 3196 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated miR-3196 as an important regulator in cancer progression. In spinal cord glioblastoma, differential miRNA analysis identified miR-3196 among several candidates with altered expression between high‐grade and low‐grade tumors, suggesting that its target genes may contribute to glioma development and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung cancer cells, mechanistic studies have further elucidated the function of miR-3196. Its expression is directly regulated by phosphorylated H2AX, which binds to the miR-3196 promoter and induces chromatin modifications that suppress its transcription. Downregulation of miR-3196 in this context relieves its inhibitory effect on apoptosis by enabling the pro-apoptotic protein PUMA, thereby promoting cell survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations in breast and gastric cancers have highlighted the broader relevance of miR-3196 in tumor biology. In these malignancies, miR-3196 has been shown to modulate cell proliferation and apoptosis, indicating its potential as both a prognostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tian An, Tao Fan, Xin Qing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparison of Alterations in miRNA Expression in Matched Tissue and Blood Samples during Spinal Cord Glioma Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-42364-x"}], "href": "https://doi.org/10.1038/s41598-019-42364-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31235820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31235820"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chengshan Xu, Ling Zhang, Lianning Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUMA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12794"}], "href": "https://doi.org/10.18632/oncotarget.12794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27780918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27780918"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Z-C Ji, S-H Han, Y-F Xing "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miR-3196 suppresses cell proliferation and induces cell apoptosis through targeting ERBB3 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201812_16536"}], "href": "https://doi.org/10.26355/eurrev_201812_16536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30556879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30556879"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Guo Chen, Jinliang Wan, Zhenbo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3196 acts as a Tumor Suppressor and Predicts Survival Outcomes in Patients With Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820923427"}], "href": "https://doi.org/10.1177/1533033820923427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32419651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32419651"}]}]}]}
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| Synonyms | MIR-3196 |
| NCBI Gene ID | 100423014 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR3196 has 332 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.
Click the + buttons to view associations for MIR3196 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR3196 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR3196 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR3196 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3196 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR3196 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR3196 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR3196 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR3196 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR3196 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |