{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into diabetic retinopathy (DR) have highlighted the clinical potential of circulating microRNAs, notably MIR3197. In a case–control study comparing DR patients with well-matched type 2 diabetic controls, MIR3197 was identified via microarray analysis as significantly upregulated in the serum of DR cases. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and receiver operating characteristic (ROC) curve analysis further substantiated its diagnostic value, suggesting that elevated levels of MIR3197 could serve as a promising biomarker for the early detection of DR."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In addition to demonstrating robust diagnostic performance, the study underscored the need for additional research to elucidate the molecular mechanisms underlying MIR3197’s role in the pathogenesis of DR. While the study also identified another miRNA, miR-2116-5p, which regulates its target gene NOTCH2, the specific functional contributions of MIR3197 in disease progression remain to be further explored."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Huihui Ji, Quanyong Yi, Lishuang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-3197 and miR-2116-5p as novel biomarkers for diabetic retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2019.10.036"}], "href": "https://doi.org/10.1016/j.cca.2019.10.036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31678272"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31678272"}]}]}]}