{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe microRNA MIR3198-1 has emerged as a modulator of cellular responses in disparate pathological settings, acting as a regulator of gene expression during processes that require tissue remodeling. In the context of orthodontic tooth movement (OTM), mechanical forces—compression and tension—applied to periodontal ligament (PDL) cells alter microRNA expression profiles that are crucial for bone homeostasis. One study demonstrated that manipulating MIR3198-1 levels via transfection of its mimic and inhibitor in immortalized human PDL cells modulates osteoprotegerin (OPG) expression, a key regulator of osteoclastogenesis and bone resorption, thereby suggesting that MIR3198-1 contributes to the mechanotransduction processes guiding osteoclast differentiation and activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn another investigation addressing preeclampsia—a vascular remodeling disorder linked to trophoblast dysfunction—maternal exosomal microRNAs were implicated in perturbing the balance of trophoblast proliferation, migration, and apoptosis. Although this study broadly focused on exosomal microRNAs without exclusively isolating MIR3198-1, its inclusion in the array of microRNAs carried by maternal exosomes suggests a potential role in mediating the cellular defects that underlie the disorder. Through possible impacts on critical regulatory pathways in trophoblast cells, aberrant MIR3198-1 expression may contribute to the placental and vascular dysfunction observed in preeclampsia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hiroyuki Kanzaki, Satoshi Wada, Yuuki Yamaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Compression and tension variably alter Osteoprotegerin expression via miR-3198 in periodontal ligament cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12860-019-0187-2"}], "href": "https://doi.org/10.1186/s12860-019-0187-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31041888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31041888"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuchen Li, Yanling Yu, Dejun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal encapsulation of miR-3198 promotes proliferation and migration of trophoblasts in preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Assist Reprod Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10815-024-03104-x"}], "href": "https://doi.org/10.1007/s10815-024-03104-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38536597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38536597"}]}]}]}