{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn studies exploring the molecular response to orthodontic tooth movement, MIR3198-2 was found to be an important regulator in periodontal ligament cells subjected to mechanical forces. When compression or tension is applied to these cells, differential miRNA expression profiles are generated, with MIR3198-2 playing a role in controlling the levels of osteoprotegerin (OPG), a key inhibitor of osteoclastogenesis. Functional experiments using a miR-3198 mimic and inhibitor demonstrated that manipulation of MIR3198-2 levels directly influences OPG expression and production, suggesting that this miRNA modulates the delicate balance between bone resorption and formation during orthodontic tooth movement."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hiroyuki Kanzaki, Satoshi Wada, Yuuki Yamaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Compression and tension variably alter Osteoprotegerin expression via miR-3198 in periodontal ligament cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12860-019-0187-2"}], "href": "https://doi.org/10.1186/s12860-019-0187-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31041888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31041888"}]}]}]}