MIR3200 Gene

HGNC Family Non-coding RNAs
Name microRNA 3200
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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This interaction downregulates MIR3200‑5p levels, which in turn facilitates the upregulation of PEBP1. As a result, the circMTO1/MIR3200‑5p/PEBP1 axis contributes to the inhibition of cell proliferation, migration, invasion, and the epithelial–mesenchymal transition, thereby decelerating cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn other malignancies, MIR3200 exhibits context‐dependent roles. In osteosarcoma, upregulation of MIR3200‑5p suppresses the metastasis suppressor BRMS1 by binding its 3′‑UTR, which leads to enhanced tumor cell invasion and migration. Conversely, in glioma, MIR3200‑3p is significantly downregulated; its restoration suppresses cell proliferation and metastasis through targeting CAMK2A and modulating the Ras/Raf/MEK/ERK signaling cascade."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lulu Guan, Feifei Wang, Mengjiao Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR-3200-5p/ATF4 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/9613095"}], "href": "https://doi.org/10.1155/2022/9613095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35615577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35615577"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanqing Feng, Gang Wei, Linfei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1982272"}], "href": "https://doi.org/10.1080/21655979.2021.1982272"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34596006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34596006"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kefeng Hu, Xiaoxuan Qin, Yongfu Shao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR-3200-5p and targeting PEBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2020.101562"}], "href": "https://doi.org/10.1016/j.mcp.2020.101562"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32194149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32194149"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gen Li, Li Li, Qi Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2018.2200"}], "href": "https://doi.org/10.14348/molcells.2018.2200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29890825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29890825"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Haibin Wang, Zhaobin Zeng, Renhui Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3200-3p targeting CAMK2A modulates the proliferation and metastasis of glioma "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "in vitro"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2048995"}], "href": "https://doi.org/10.1080/21655979.2022.2048995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35287547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35287547"}]}]}]}
Synonyms MIR-3200
NCBI Gene ID 100422912
API
Download Associations
Predicted Functions View MIR3200's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3200's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3200's ARCHS4 Predicted Functions.

Functional Associations

MIR3200 has 312 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR3200 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3200 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3200 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3200 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3200 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3200 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3200 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3200 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3200 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3200 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.