MIR3201 Gene

HGNC Family Non-coding RNAs
Name microRNA 3201
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent genome-wide association studies have highlighted the importance of the APOA5/A4/C3/A1 gene cluster in influencing triglyceride levels and the risk of coronary artery disease (CAD). Emerging evidence indicates that MIR3201, a microRNA with potential regulatory function, may participate in this pathway by modulating the expression levels of genes within this cluster. Through post‐transcriptional regulation, MIR3201 could help fine‐tune lipid metabolism, thereby contributing to the variation in plasma triglyceride levels and, ultimately, cardiovascular risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn this regulatory context, MIR3201 appears to act as a molecular switch that integrates genetic predispositions with environmental cues affecting lipid homeostasis. Its interaction with target mRNAs from the APOA5/A4/C3/A1 cluster may offer novel insights into the mechanisms underlying CAD, providing a potential link between non‐coding RNA activity and the modulation of disease‐related phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guanglin Cui, Zongzhe Li, Rui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional variant in APOA5/A4/C3/A1 gene cluster contributes to elevated triglycerides and severity of CAD by interfering with microRNA 3201 binding efficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Coll Cardiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jacc.2014.03.050"}], "href": "https://doi.org/10.1016/j.jacc.2014.03.050"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25034063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25034063"}]}]}]}
NCBI Gene ID 100422916
API
Download Associations
Predicted Functions View MIR3201's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3201's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3201's ARCHS4 Predicted Functions.

Functional Associations

MIR3201 has 195 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3201 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3201 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3201 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3201 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3201 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3201 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR3201 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3201 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3201 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3201 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3201 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.