{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have demonstrated that MIR3202‑1 functions as a critical regulator of cell survival via its modulation of the antiapoptotic factor FAIM2. In chronic obstructive pulmonary disease (COPD), lowered levels of miR‑3202 in blood and T lymphocytes correlate with increased FAIM2 expression, heightened inflammatory cytokine production, and epithelial apoptosis, while its overexpression exerts a protective effect on bronchial epithelial cells. In a parallel investigation concerning facioscapulohumeral muscular dystrophy (FSHD), miR‑3202 was shown to target FAIM2, and inhibition of miR‑3202 resulted in enhanced FAIM2 levels that contributed to DUX4‑induced cell death and impaired myoblast differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic analyses have further implicated MIR3202‑1 in oncogenesis; a functional variant within the miR‑3202 gene that affects its regulation of the MeCP2 protein is significantly associated with lung cancer, suggesting that alterations in MIR3202‑1 may serve both as a biomarker and as an influential factor in the development of malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional research places miR‑3202 within broader microRNA–mRNA networks involved in immune and developmental pulmonary conditions. In primary Sjögren’s syndrome, miR‑3202 forms part of the regulatory circuitry associated with lymphocyte infiltration and inflammation, while in bronchopulmonary dysplasia—a disease affecting the developing lungs of preterm infants—its potential role in the underlying pathogenic mechanisms remains an important subject for further investigation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wen Shen, Jia Liu, Minjuan Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3202 protects smokers from chronic obstructive pulmonary disease through inhibiting FAIM2: An in vivo and in vitro study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2017.11.038"}], "href": "https://doi.org/10.1016/j.yexcr.2017.11.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29208459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29208459"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hossam A N Soliman, Erik A Toso, Inas E Darwish, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antiapoptotic Protein FAIM2 is targeted by miR-3202, and DUX4 via TRIM21, leading to cell death and defective myogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-04804-x"}], "href": "https://doi.org/10.1038/s41419-022-04804-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35468884"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35468884"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Cansu Ozbayer, Irfan Degirmenci, Derya Ustuner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRSNPs of miR1274 and miR3202 Genes that Target MeCP2 and DNMT3b Are Associated with Lung Cancer Risk: A Study Conducted on MassARRAY Genotyping."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Environ Pathol Toxicol Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/JEnvironPatholToxicolOncol.2016016320"}], "href": "https://doi.org/10.1615/JEnvironPatholToxicolOncol.2016016320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27910778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27910778"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qi Gao, Zhuang Ye, Tao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-miR-3202 attenuates Jurkat cell infiltration via MMP2 in primary Sjögren's syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Pathol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jop.13355"}], "href": "https://doi.org/10.1111/jop.13355"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36076347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36076347"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Li-Chun Zeng, Shu-Hui Zhang, Na Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3202 inhibits bronchopulmonary dysplasia-mediated apoptosis and oxidative stress in bronchial epithelial cells via targeting RAG1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2024.155482"}], "href": "https://doi.org/10.1016/j.prp.2024.155482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39067173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39067173"}]}]}]}