{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR324 is generated from a common precursor yielding two distinct mature forms (miR‐324‐3p and miR‐324‐5p) that exert context‐dependent functions in cancer. In several studies, upregulation of miR‐324 (for example, via metformin treatment in breast cancer) has been shown to promote cell death mechanisms such as ferroptosis by downregulating targets like GPX4, while in other tumor types miR‐324 functions as a tumor suppressor by inhibiting cell proliferation, migration and invasion. In hepatocellular carcinoma, ectopic expression of miR‐324‐5p suppresses invasive behavior through direct targeting of ETS1 and SP1; in colorectal cancer it limits cell viability and invasive capacity by downregulating ELAVL1; and in nasopharyngeal and thyroid carcinomas, as well as in cholangiocarcinoma, aberrant levels of miR‐324 are associated with therapy resistance and poor prognosis. These findings collectively indicate that the precise control of miR‐324 expression and the selection of its arm play key roles in modulating oncogenic signaling pathways and the tumor microenvironment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond malignancy, MIR324‐5p has been implicated in regulating non‐cancer processes that include host defense and the maintenance of tissue homeostasis. In models of viral infection, miR‐324‐5p represses pathogen replication—notably by targeting components of the influenza viral genome as well as cellular inhibitors of interferon responses—thereby contributing to antiviral defense. In cardiovascular and metabolic contexts, miR‐324‐5p protects endothelial progenitor cells from oxidative stress, modulates cardiomyocyte survival during hypoxia/reoxygenation through regulation of SOCS3 and TNF/NF‐κB signaling, and influences glucose and lipid metabolism via targeting of key regulators such as ROCK1. Such studies underscore its role in attenuating vascular remodeling, myocardial injury, and metabolic dysregulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMIR324’s regulatory impact is often achieved through its integration into complex noncoding RNA networks. Several studies have demonstrated that long non‐coding RNAs and circular RNAs act as “sponges” for miR‐324, thereby modulating its availability and downstream target regulation. For example, in neurodegenerative models the lncRNA RP11–543N12.1 sequesters miR‐324‐3p to affect neuronal apoptosis, while in reproductive and endocrine disorders such as polycystic ovary syndrome, specific circRNAs bind miR‐324‐3p to regulate kinases like MAP2K6. Similar ceRNA mechanisms have been described in glioma and melanoma, further highlighting how modulation of MIR324 levels by competing endogenous RNAs contributes to disease progression and represents a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "28", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liangqi Cao, Binhui Xie, Xuewei Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0133074"}], "href": "https://doi.org/10.1371/journal.pone.0133074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26177288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26177288"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jianhua Xu, Qin Ai, Hanhai Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-185-3p and miR-324-3p Predict Radiosensitivity of Nasopharyngeal Carcinoma and Modulate Cancer Cell Growth and Apoptosis by Targeting SMAD7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.895660"}], "href": "https://doi.org/10.12659/MSM.895660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26390174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26390174"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xujie Gao, Yang Wang, Hua Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma miR-324-3p and miR-1285 as diagnostic and prognostic biomarkers for early stage lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11198"}], "href": "https://doi.org/10.18632/oncotarget.11198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27517633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27517633"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei-Ting Kuo, Shou-Yu Yu, Sung-Chou Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-324 in Human Cancer: miR-324-5p and miR-324-3p Have Distinct Biological Functions in Human Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21873/anticanres.11089"}], "href": "https://doi.org/10.21873/anticanres.11089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27798879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27798879"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Bo Tang, Aoshuang Xu, Jian Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-324-5p regulates stemness, pathogenesis and sensitivity to bortezomib in multiple myeloma cells by targeting hedgehog signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31041"}], "href": "https://doi.org/10.1002/ijc.31041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28905994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28905994"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Guang-Li Sun, Zheng Li, Wei-Zhi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00535-017-1408-0"}], "href": "https://doi.org/10.1007/s00535-017-1408-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29103082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29103082"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chijiang Gu, Mingyuan Zhang, Weiliang Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-324-5p Inhibits Proliferation and Invasion of Colorectal Cancer Cells by Targeting ELAVL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504018X15166183598572"}], "href": "https://doi.org/10.3727/096504018X15166183598572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29386086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29386086"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hai Lin, Ai-Jun Zhou, Jing-Yu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-324-5p reduces viability and induces apoptosis in gastric cancer cells through modulating TSPAN8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pharm Pharmacol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jphp.12995"}], "href": "https://doi.org/10.1111/jphp.12995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30159900"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30159900"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xinrong Zhang, Lei Zhang, Ming Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-324-5p inhibits gallbladder carcinoma cell metastatic behaviours by downregulation of transforming growth factor beta 2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1703724"}], "href": "https://doi.org/10.1080/21691401.2019.1703724"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31858815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31858815"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Feifei Liu, Yang Xiao, Lijing Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulating of cell cycle progression by the lncRNA CDKN2B-AS1/miR-324-5p/ROCK1 axis in laryngeal squamous cell cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Markers (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1724600819898489"}], "href": "https://doi.org/10.1177/1724600819898489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31960744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31960744"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yanhua Yang, Shujun Xia, Lu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-324-5p/PTPRD/CEBPD axis promotes papillary thyroid carcinoma progression via microenvironment alteration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2020.1736465"}], "href": "https://doi.org/10.1080/15384047.2020.1736465"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32151175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32151175"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ming-Jun Fan, Peng-Juan He, Xue-Yan Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-324-5p affects the radiotherapy response of cervical cancer via targeting ELAV-like RNA binding protein 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12277"}], "href": "https://doi.org/10.1002/kjm2.12277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32757457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32757457"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yin Peng, Xiaojing Zhang, Huijuan Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SUFU mediates EMT and Wnt/β-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2020.1826632"}], "href": "https://doi.org/10.1080/15384101.2020.1826632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33017570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33017570"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yun Liu, Yue Chang, Yixuan Cai "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0067835 sponges miR-324-5p to induce HMGA1 expression in endometrial carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15996"}], "href": "https://doi.org/10.1111/jcmm.15996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33169939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33169939"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yifeng Hou, Shuang Cai, Shouyang Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmaa180"}], "href": "https://doi.org/10.1093/abbs/gmaa180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33522578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33522578"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Atefeh Zamani, Nasrin Fattahi Dolatabadi, Massoud Houshmand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-324-3p and miR-508-5p expression levels could serve as potential diagnostic and multidrug-resistant biomarkers in childhood acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2021.106643"}], "href": "https://doi.org/10.1016/j.leukres.2021.106643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34147937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34147937"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Li Geng, Zhongqiu Wang, Yongju Tian "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of ZNF252P-AS1 alleviates ovarian cancer progression by binding miR-324-3p to downregulate LY6K."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Ovarian Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13048-021-00933-7"}], "href": "https://doi.org/10.1186/s13048-021-00933-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34980214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34980214"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Fengjie Li, Zhen Liang, Yongqin Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-324-3p suppresses the aggressive ovarian cancer by targeting "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "WNK2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "/RAS pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2056314"}], "href": "https://doi.org/10.1080/21655979.2022.2056314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35549643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35549643"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kang Wang, Qing Luo, Yingfeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.204413"}], "href": "https://doi.org/10.18632/aging.204413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36462499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36462499"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Dagmara Szkolnicka, Baltasar Lucendo-Villarin, Joanna K Moore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Transl Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5966/sctm.2015-0117"}], "href": "https://doi.org/10.5966/sctm.2015-0117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27057006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27057006"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ashish Kumar, Akhilesh Kumar, Harshad Ingle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01057-18"}], "href": "https://doi.org/10.1128/JVI.01057-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30045983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30045983"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Peier Chen, Jianfeng Zhong, Jianfeng Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-324-5p protects against oxidative stress-induced endothelial progenitor cell injury by targeting Mtfr1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28771"}], "href": "https://doi.org/10.1002/jcp.28771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31066044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31066044"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hebah A Sindi, Giusy Russomanno, Sandro Satta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-14966-x"}], "href": "https://doi.org/10.1038/s41467-020-14966-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32132543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32132543"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jun Guo, Chunxiao Yang, Yajun Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced peripheral blood miR-324-5p is associated with the risk of metabolic syndrome by suppressing ROCK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Biol Lipids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2020.158727"}], "href": "https://doi.org/10.1016/j.bbalip.2020.158727"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32353552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32353552"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Xuefu Han, Xi Chen, Jiaqi Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-324/SOCS3 Axis Protects Against Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury and Regulates Myocardial Ischemia via TNF/NF-κB Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Heart J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1536/ihj.19-687"}], "href": "https://doi.org/10.1536/ihj.19-687"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33191336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33191336"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Aiping Jin, Qianrong Zhang, Haijuan Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2022.108740"}], "href": "https://doi.org/10.1016/j.intimp.2022.108740"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35413678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35413678"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Xiaoyan Dou, Xiaoliang Yu, Shujing Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interferon-mediated repression of miR-324-5p potentiates necroptosis to facilitate antiviral defense."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.202154438"}], "href": "https://doi.org/10.15252/embr.202154438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35735238"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35735238"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Miao Cai, Yan-Wen Wang, Shan-Hu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulatory effects of the long non‑coding RNA RP11‑543N12.1 and microRNA‑324‑3p axis on the neuronal apoptosis induced by the inflammatory reactions of microglia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2018.3736"}], "href": "https://doi.org/10.3892/ijmm.2018.3736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29956723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29956723"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Ho-Hyung Woo, Setsuko K Chambers "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of closely juxtaposed proto-oncogene "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "c-fms"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HMGXB3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene expression by mRNA 3' end polymorphism in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.078749.121"}], "href": "https://doi.org/10.1261/rna.078749.121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34155128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34155128"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Cheng Gao, Jifeng Sun, Zhihua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NEAT1 Boosts the Development of Thoracic Aortic Aneurysm Through Targeting miR-324-5p/RAN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Med Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.arcmed.2021.06.009"}], "href": "https://doi.org/10.1016/j.arcmed.2021.06.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34373133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34373133"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Peng Tu, Sujuan Yan, Fengping Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-022-10238-z"}], "href": "https://doi.org/10.1007/s10528-022-10238-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35689709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35689709"}]}]}]}