MIR325 Gene

HGNC Family Non-coding RNAs
Name microRNA 325
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that miR-325 is a versatile regulatory microRNA implicated in both non‐malignant disorders and tumorigenesis. For example, genetic investigations have linked polymorphisms in the primary miR‑325 coding region with functional dyspepsia, suggesting that alterations in its biogenesis may contribute to gastrointestinal susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In pregnancy, reduced placental expression of miR‑325 has been observed in preeclampsia, with decreased levels correlating with altered blood pressure and body mass index that may affect oxidative stress pathways and heat‐shock protein production."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the cancer arena, miR‑325‑3p predominantly functions as a tumor suppressor. In non‐small cell lung cancer (NSCLC), its downregulation is associated with enhanced cell proliferation and invasion via derepression of targets such as HMGB1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In bladder cancer, early evidence suggests that miR‑325 may serve as a biomarker and tumor regulator, with reduced expression linked to aberrant cellular growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, in NSCLC, miR‑325‑3p targets oncogenic factors such as KIF2C, whose elevated expression correlates with advanced tumor stage and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In bladder cancer cells, downregulation of miR‑325‑3p leads to increased expression of metallothionein 3 (MT3), and restoration of miR‑325‑3p not only suppresses cell proliferation, migration, invasion, and epithelial–mesenchymal transition but also reverses cisplatin resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Its role in hepatocellular carcinoma has also been highlighted, indicating that dysregulation of miR‑325‑3p may contribute to tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In nasopharyngeal carcinoma, miR‑325 is sequestered by the long non‑coding RNA LINC01515, thereby failing to suppress CDCA5 and facilitating tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Furthermore, aberrant expression of miR‑325‑3p in acute pancreatitis points to a broader role in inflammatory responses"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", while additional work in NSCLC shows that miR‑325‑3p negatively regulates DNA ligase 1 (LIG1), a key enzyme in DNA replication and repair, further underlining its tumor‑suppressive function and potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tomiyasu Arisawa, Tomomitsu Tahara, Tomoki Fukuyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphism of pri-microRNA 325, targeting SLC6A4 3'-UTR, is closely associated with the risk of functional dyspepsia in Japan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00535-012-0576-1"}], "href": "https://doi.org/10.1007/s00535-012-0576-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22438098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22438098"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Levente Lázár, Bálint Nagy, Attila Molvarec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of hsa-miR-325 in the etiopathology of preeclampsia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2012.954"}], "href": "https://doi.org/10.3892/mmr.2012.954"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22710575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22710575"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shihua Yao, Tiejun Zhao, Hai Jin "}, {"type": "b", "children": [{"type": "t", "text": "Expression of MicroRNA-325-3p and its potential functions by targeting HMGB1 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2015.01.013"}], "href": "https://doi.org/10.1016/j.biopha.2015.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25776482"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25776482"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tao Lin, Shiming Zhou, Hui Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-325 Is a Potential Biomarker and Tumor Regulator in Human Bladder Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033818790536"}], "href": "https://doi.org/10.1177/1533033818790536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30176759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30176759"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Huizhu Gan, Lin Lin, Nanjun Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Funct (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cbf.3420"}], "href": "https://doi.org/10.1002/cbf.3420"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31328811"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31328811"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shaopeng Sun, Feng Liu, Shaozhong Xian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-325-3p Overexpression Inhibits Proliferation and Metastasis of Bladder Cancer Cells by Regulating MT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.920331"}], "href": "https://doi.org/10.12659/MSM.920331"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32512576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32512576"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "R Li, J-Z Zheng, X Huang "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of HAX-1 induced by miR-325 resensitizes bladder cancer cells to cisplatin-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202009_23012"}], "href": "https://doi.org/10.26355/eurrev_202009_23012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33015771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33015771"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Li Li, Yong Ji, Ya-Cun Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-325-3p mediate the CXCL17/CXCR8 axis to regulate angiogenesis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cyto.2021.155436"}], "href": "https://doi.org/10.1016/j.cyto.2021.155436"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33515898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33515898"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dan Liu, Hao Gong, Zezhang Tao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Histol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10735-021-09969-x"}], "href": "https://doi.org/10.1007/s10735-021-09969-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33770322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33770322"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ao Jia, Zhen-Wei Yang, Ji-Yu Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-325-3p Alleviates Acute Pancreatitis via Targeting RIPK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-021-07322-6"}], "href": "https://doi.org/10.1007/s10620-021-07322-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35094251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35094251"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Maixia Yu, Linchan Li, Peng Xu "}, {"type": "b", "children": [{"type": "t", "text": "miR-325 Supresses Cell Proliferation and Migration in Non-Small Cell Lung Cancer via Targeting DNA Ligase 1 (LIG1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Folia Biol (Praha) (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14712/fb2024070020095"}], "href": "https://doi.org/10.14712/fb2024070020095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39231317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39231317"}]}]}]}
Synonyms HSA-MIR-325, MIRN325
NCBI Gene ID 442899
API
Download Associations
Predicted Functions View MIR325's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR325's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR325's ARCHS4 Predicted Functions.

Functional Associations

MIR325 has 111 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.

Click the + buttons to view associations for MIR325 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR325 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR325 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
CTD Gene-Disease Associations diseases associated with MIR325 gene/protein from the curated CTD Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR325 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR325 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR325 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR325 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.