MIR329-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 329-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In oral cancer, it is predicted to target Wnt‑7b to attenuate Wnt/β‑catenin signaling; in gastric cancer, it targets TIAM1 and KDM1A; in pituitary tumors, it downregulates PTTG1; in lung cancer, its repression of MET curtails cell cycle progression while enhancing apoptotic programs; and in breast cancer, its inhibition of p130Cas reduces migration and proliferation. Additionally, miR‑329 modulates angiogenesis through targeting CD146 in endothelial cells, diminishes neuroblastoma aggressiveness by regulating KDM1A, suppresses osteosarcoma growth via Rab10 inhibition, curbs pancreatic cancer progression by downregulating GRB2 and the pERK pathway, attenuates melanoma advancement by targeting HMGB2, and reverses epithelial‐to‐mesenchymal transition in bile duct cancer through repression of LAMB3. Its targeting of E2F1 in endometrial carcinoma further substantiates its broad regulatory impact on tumorigenic processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also highlights miR‑329’s applicability in other clinically relevant contexts, including hepatocellular carcinoma, where its altered expression patterns further reinforce its role as a master regulator of tumor progression and a promising candidate for targeted therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bingxiang Xiao, Li Tan, Benfu He, et al. 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Synonyms MIRN329-1, MIR-329-1
NCBI Gene ID 574408
API
Download Associations
Predicted Functions View MIR329-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR329-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR329-1's ARCHS4 Predicted Functions.

Functional Associations

MIR329-1 has 254 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.

Click the + buttons to view associations for MIR329-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR329-1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR329-1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR329-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR329-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR329-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR329-1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR329-1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR329-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR329-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR329-1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR329-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.