| HGNC Family | Non-coding RNAs |
| Name | microRNA 33b |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐33b is co‐expressed with the sterol regulatory element‐binding proteins and plays a central role in lipid and glucose homeostasis. It post‐transcriptionally represses key targets such as ATP‐binding cassette transporter A1 (ABCA1) to coordinate cholesterol efflux, high‐density lipoprotein (HDL) formation, fatty acid oxidation, and hepatic gluconeogenesis. By fine‐tuning these metabolic pathways, miR‐33b contributes not only to the maintenance of lipid profiles and energy balance but also to the development of cardiometabolic disorders, obesity, and insulin resistance. Its altered circulating levels have been proposed as early biomarkers for dyslipidemia and other metabolic states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various cancer settings, miR‐33b functions predominantly as a tumor suppressor. Its downregulation has been associated with enhanced cell proliferation, migration, invasion, and metastasis in malignancies including medulloblastoma, breast cancer, melanoma, lung adenocarcinoma, gastric cancer, glioma, esophageal squamous cell carcinoma, gallbladder cancer, and acute myelocytic leukemia. miR‐33b exerts its anti‐tumor effects by directly targeting oncogenic drivers such as c‐Myc, HMGA2, Twist1, ZEB1, lactate dehydrogenase‐A (LDHA), and other regulators of epithelial–mesenchymal transition and glycolysis, thereby reprogramming cancer cell metabolism and sensitizing cells to chemotherapeutic agents."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its cardinal roles in metabolism and oncogenesis, miR‐33b modulates a spectrum of cellular processes that impact inflammatory responses, autophagy, vascular cell function, and even viral replication. It regulates autophagy in macrophages to influence cholesterol handling and atherogenesis, impacts energy metabolism via the PI3K/Akt pathway in foam cells, and affects smooth muscle cell phenotype in vascular disorders such as aortic dissection. Moreover, miR‐33b modulation alters the cellular response to DNA damage and chemotherapeutic stress, while its interactions with long noncoding RNAs or circular RNAs can further influence processes including epithelial–mesenchymal transition, inflammation in osteoarthritis, and adverse outcomes in preeclampsia. These multifunctional roles underscore miR‐33b’s potential not only as a biomarker but also as a therapeutic target in diverse pathological conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "32", "end_ref": "39"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S Hani Najafi-Shoushtari, Fjoralba Kristo, Yingxia Li, et al. 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| Synonyms | HSA-MIR-33B, MIR-33B, MIRN33B |
| NCBI Gene ID | 693120 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MIR33B has 888 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.
Click the + buttons to view associations for MIR33B from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR33B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR33B gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MIR33B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR33B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR33B gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR33B gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR33B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MIR33B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MIR33B from the GeneSigDB Published Gene Signatures dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MIR33B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR33B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR33B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MIR33B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR33B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of MIR33B gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR33B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| WikiPathways Pathways 2014 | pathways involving MIR33B protein from the Wikipathways Pathways 2014 dataset. | |