{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMicroRNA‐340 (miR‐340) has emerged as a pivotal regulator in cancer biology. In numerous solid tumors—including breast, colorectal, osteosarcoma, non‐small cell lung cancer, glioblastoma, esophageal, prostate, ovarian, and gastric carcinomas—miR‐340 is commonly downregulated. This reduced expression is often associated with enhanced tumor aggressiveness, metastasis, and poor clinical outcome, underscoring its role as a tumor suppressor. In some contexts, however, aberrant elevation of miR‐340 has been reported, suggesting that its function may be context‐dependent. Among the studies highlighting these associations are those reporting miR‐340 as a promising biomarker for early detection and prognosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, miR‐340 executes its tumor‐suppressive functions by directly targeting multiple oncogenic transcripts and regulatory pathways. Several investigations have described its ability to modulate key effectors involved in cell cycle control, apoptosis, invasion, and metabolism. In colorectal disseminated tumor cells, for instance, miR‐340 downregulation correlated with metastatic potential"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ", while in melanoma it regulates MITF as well as stem cell markers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "22"}]}, {"type": "t", "text": " In hepatocellular carcinoma, targeting of Nrf2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": ", and in glioma‐initiating cells, repression of PLAT"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": ", have been implicated in reducing chemoresistance and stem‐like properties. Additional findings demonstrate that miR‐340 controls alternative splicing events in oral squamous cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": "and regulates ABCB5 expression in melanoma stem‐like cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": " Its modulation of other oncogenic pathways—including EZH2 in laryngeal carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": ", MDM2‐p53 signaling in prostate cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", Wnt/β‐catenin signaling in invasive breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and NRAS in glioblastoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": "—further supports its role in controlling cell proliferation and survival. In endometrial carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": ", radiotherapy‐induced inflammatory signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "30"}]}, {"type": "t", "text": ", and hepatocellular carcinoma via JAK1/STAT3 modulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "31"}]}, {"type": "t", "text": ", miR‐340 is shown to influence both intrinsic tumor cell properties and the tumor microenvironment. Its targeting of prognostic factors such as LGR5 in breast cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "32"}]}, {"type": "t", "text": ", NT5E in gallbladder carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "33"}]}, {"type": "t", "text": ", and ZEB1 in osteosarcoma chemoresistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "34"}]}, {"type": "t", "text": ", as well as its action on SIRT7 in angiosarcoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "35"}]}, {"type": "t", "text": ", and regulation of CDK4 in non‐small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "36"}]}, {"type": "t", "text": ", collectively illustrate its multifaceted inhibitory effects. Further, its role in modulating ARG1 expression in acute stroke"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "37"}]}, {"type": "t", "text": ", the epigenetic regulation noted in multiple myeloma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "38"}]}, {"type": "t", "text": ", additional growth‐suppressive activity in NSCLC"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "39"}]}, {"type": "t", "text": ", and its sequestration by LINC00662 in acute myeloid leukemia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "40"}]}, {"type": "t", "text": ", further substantiate the diverse molecular mechanisms by which miR‐340 tempers oncogenic signaling. Notably, a review article has contextualized these diverse findings, reinforcing the notion that miR‐340’s regulatory network is both broad and clinically significant."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in established malignancies, emerging evidence implicates miR‐340 in modulating the tumor microenvironment and other systemic processes. For example, altered miR‐340 expression has been observed in the peripheral blood in conditions such as gestational diabetes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "41"}]}, {"type": "t", "text": "and in response to acute ischemic stroke."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "37"}]}, {"type": "t", "text": " In cardiovascular research, differences in miRNA profiles in platelets from patients with coronary artery disease have also been reported, suggesting that miR‐340 might have broader diagnostic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "42"}]}, {"type": "t", "text": " Collectively, these findings indicate that miR‐340 not only serves as a critical intra‐tumoral modulator of proliferation, apoptosis, and invasion but also represents a promising candidate for therapeutic intervention and biomarker development across a range of pathological conditions.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zheng-sheng Wu, Qiang Wu, Chao-qun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.25860"}], "href": "https://doi.org/10.1002/cncr.25860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21692045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21692045"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Sun, Xiaoping Zhao, Yuhong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2012.1958"}], "href": "https://doi.org/10.3892/or.2012.1958"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22895557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22895557"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xin Zhou, Min Wei, Wei Wang "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.07.033"}], "href": "https://doi.org/10.1016/j.bbrc.2013.07.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23872151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23872151"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "S Fernandez, M Risolino, N Mandia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.267"}], "href": "https://doi.org/10.1038/onc.2014.267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25151966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25151966"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xuesong Li, Xuhai Gong, Jing Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.03.088"}], "href": "https://doi.org/10.1016/j.bbrc.2015.03.088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25817794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25817794"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Daquan Huang, Shuwei Qiu, Ruiguang Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340 suppresses glioblastoma multiforme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3288"}], "href": "https://doi.org/10.18632/oncotarget.3288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25831237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25831237"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Shuo Yan, Haosheng Jiang, Shiming Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000430361"}], "href": "https://doi.org/10.1159/000430361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26316084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26316084"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pengtao Wei, Baoping Qiao, Qi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-340 Suppresses Tumorigenic Potential of Prostate Cancer Cells by Targeting High-Mobility Group Nucleosome-Binding Domain 5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2015.3021"}], "href": "https://doi.org/10.1089/dna.2015.3021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26394192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26394192"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Cai-Ping Chen, Zong-Lin Sun, Xiang Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-340 suppresses cell migration and invasion by targeting MYO10 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4411"}], "href": "https://doi.org/10.3892/or.2015.4411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26573744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26573744"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kai Huang, Yuxin Tang, Leye He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 inhibits prostate cancer cell proliferation and metastasis by targeting the MDM2-p53 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.4458"}], "href": "https://doi.org/10.3892/or.2015.4458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26718483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26718483"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Samira Mohammadi-Yeganeh, Mahdi Paryan, Ehsan Arefian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 inhibits the migration, invasion, and metastasis of breast cancer cells by targeting Wnt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4513-9"}], "href": "https://doi.org/10.1007/s13277-015-4513-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26758430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26758430"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Peiquan Li, Yuxin Sun, Qing Liu "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 Induces Apoptosis and Inhibits Metastasis of Ovarian Cancer Cells by Inactivation of NF-x03BA;B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000445553"}], "href": "https://doi.org/10.1159/000445553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27160777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27160777"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "S Mohammadi Yeganeh, M Vasei, R Tavakoli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of miR-340 over-expression on cell-cycle-related genes in triple-negative breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer Care (Engl) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ecc.12496"}], "href": "https://doi.org/10.1111/ecc.12496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27229858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27229858"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jinzhong Yu, Ruijie Wang, Jianshe Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340 Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cell Line SGC-7901, Possibly via the AKT Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.898449"}], "href": "https://doi.org/10.12659/msm.898449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28057912"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28057912"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kewei Du, Ziqiang Li, Xuchen Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ferulic acid promotes osteogenesis of bone marrow-derived mesenchymal stem cells by inhibiting microRNA-340 to induce β-catenin expression through hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2017.07.002"}], "href": "https://doi.org/10.1016/j.ejcb.2017.07.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28764862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28764862"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Tingting Huang, Yuhang Zhou, Jinglin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SRGAP1, a crucial target of miR-340 and miR-124, functions as a potential oncogene in gastric tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-017-0029-7"}], "href": "https://doi.org/10.1038/s41388-017-0029-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29234151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29234151"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Shuai Shi, Xiao Chen, Hong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LGR5 acts as a target of miR-340-5p in the suppression of cell progression and drug resistance in breast cancer via Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.10.014"}], "href": "https://doi.org/10.1016/j.gene.2018.10.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30300682"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30300682"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Zheng Huang, Yesha Xu, Maoping Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340: A multifunctional role in human malignant diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.51123"}], "href": "https://doi.org/10.7150/ijbs.51123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33390846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33390846"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hiroshi Takeyama, Hirofumi Yamamoto, Shinya Yamashita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased miR-340 expression in bone marrow is associated with liver metastasis of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-13-0571"}], "href": "https://doi.org/10.1158/1535-7163.MCT-13-0571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24448820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24448820"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Qiang Jian, Qing An, Dongning Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA 340 is involved in UVB-induced dendrite formation through the regulation of RhoA expression in melanocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00106-14"}], "href": "https://doi.org/10.1128/MCB.00106-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24980435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24980435"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ashley M Poenitzsch Strong, Vijayasaradhi Setaluri, Vladimir S Spiegelman "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Biochem Biophys (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.abb.2014.07.012"}], "href": "https://doi.org/10.1016/j.abb.2014.07.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25043973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25043973"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Srikanta Goswami, Rohinton S Tarapore, Ashley M Poenitzsch Strong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.590158"}], "href": "https://doi.org/10.1074/jbc.M114.590158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25414259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25414259"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Liang Shi, Zhan-Guo Chen, Li-Li Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340 reverses cisplatin resistance of hepatocellular carcinoma cell lines by targeting Nrf2-dependent antioxidant pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2014.15.23.10439"}], "href": "https://doi.org/10.7314/apjcp.2014.15.23.10439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25556489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25556489"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Daisuke Yamashita, Toru Kondo, Shiro Ohue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR340 suppresses the stem-like cell function of glioma-initiating cells by targeting tissue plasminogen activator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-0938"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-0938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25627976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25627976"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Ping Xu, Yan Li, Haiyuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 Mediates Metabolic Shift in Oral Squamous Cell Carcinoma by Targeting Glucose Transporter-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Maxillofac Surg (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.joms.2015.09.038"}], "href": "https://doi.org/10.1016/j.joms.2015.09.038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26541225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26541225"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Michal Wozniak, Malgorzata Sztiller-Sikorska, Malgorzata Czyz "}, {"type": "b", "children": [{"type": "t", "text": "Diminution of miR-340-5p levels is responsible for increased expression of ABCB5 in melanoma cells under oxygen-deprived conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2015.11.014"}], "href": "https://doi.org/10.1016/j.yexmp.2015.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26554847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26554847"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Wenfa Yu, Guozheng Zhang, Baocai Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-340 impedes the progression of laryngeal squamous cell carcinoma by targeting EZH2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2015.11.045"}], "href": "https://doi.org/10.1016/j.gene.2015.11.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26656176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26656176"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Danilo Fiore, Elvira Donnarumma, Giuseppina Roscigno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340 predicts glioblastoma survival and modulates key cancer hallmarks through down-regulation of NRAS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6968"}], "href": "https://doi.org/10.18632/oncotarget.6968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26799668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26799668"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Wei Xie, Wen Qin, Yalin Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 Inhibits Tumor Cell Proliferation and Induces Apoptosis in Endometrial Carcinoma Cell Line RL 95-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.898121"}], "href": "https://doi.org/10.12659/msm.898121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27153225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27153225"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Eun Sook Kim, Young Eun Choi, Su Jin Hwang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-4, a direct target of miR-340/429, is involved in radiation-induced aggressive tumor behavior in human carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13561"}], "href": "https://doi.org/10.18632/oncotarget.13561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27895317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27895317"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Jianyong Yuan, Hongxiang Ji, Feng Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 inhibits the proliferation and invasion of hepatocellular carcinoma cells by targeting JAK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.12.102"}], "href": "https://doi.org/10.1016/j.bbrc.2016.12.102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27998770"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27998770"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Mithu Raychaudhuri, Holger Bronger, Theresa Buchner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs miR-7 and miR-340 predict response to neoadjuvant chemotherapy in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-017-4132-9"}], "href": "https://doi.org/10.1007/s10549-017-4132-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28181130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28181130"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Ning Wang, Xiaohui Xiang, Kai Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting of NT5E by miR-30b and miR-340 attenuates proliferation, invasion and migration of gallbladder carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochimie (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biochi.2017.10.027"}], "href": "https://doi.org/10.1016/j.biochi.2017.10.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29155108"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29155108"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Haibin Yan, Bingyun Zhang, Chongbin Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-340 alleviates chemoresistance of osteosarcoma cells by targeting ZEB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000000614"}], "href": "https://doi.org/10.1097/CAD.0000000000000614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29494357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29494357"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Xiaoxin Wang, Ying Song "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340 inhibits the growth and invasion of angiosarcoma cells by targeting SIRT7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.04.148"}], "href": "https://doi.org/10.1016/j.biopha.2018.04.148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29710664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29710664"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Yingzhi Qin, Xiaoyun Zhou, Cheng Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lower miR-340 expression predicts poor prognosis of non-small cell lung cancer and promotes cell proliferation by targeting CDK4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.06.062"}], "href": "https://doi.org/10.1016/j.gene.2018.06.062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29935356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29935356"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Hanna Yoo, Jinkwon Kim, Ae-Ri Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alteration of microRNA 340-5p and Arginase-1 Expression in Peripheral Blood Cells during Acute Ischemic Stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-018-1295-2"}], "href": "https://doi.org/10.1007/s12035-018-1295-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30112629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30112629"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Zhenhai Li, Kwan Yeung Wong, George A Calin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic silencing of miR-340-5p in multiple myeloma: mechanisms and prognostic impact."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-019-0669-2"}], "href": "https://doi.org/10.1186/s13148-019-0669-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31064412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31064412"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Guojie Lu, Yaosen Zhang "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-340-5p suppresses non-small cell lung cancer cell growth and metastasis by targeting ZNF503."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-019-0161-1"}], "href": "https://doi.org/10.1186/s11658-019-0161-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31160893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31160893"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Yuan Liu, Xiaoyan Gao, Xiaoqing Tian "}, {"type": "b", "children": [{"type": "t", "text": "High expression of long intergenic non-coding RNA LINC00662 contributes to malignant growth of acute myeloid leukemia cells by upregulating ROCK1 via sponging microRNA-340-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2019.172535"}], "href": "https://doi.org/10.1016/j.ejphar.2019.172535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31306637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31306637"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Laura Stirm, Peter Huypens, Steffen Sass, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-19200-9"}], "href": "https://doi.org/10.1038/s41598-018-19200-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29358694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29358694"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Brigitte M Sondermeijer, Annemieke Bakker, Amalia Halliani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Platelets in patients with premature coronary artery disease exhibit upregulation of miRNA340"}, {"type": "i", "children": [{"type": "t", "text": " and miRNA624"}]}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0025946"}], "href": "https://doi.org/10.1371/journal.pone.0025946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22022480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22022480"}]}]}]}