{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR34AHG, the host gene for miR-34a, has been implicated in tumor suppression by regulating key pathways that control cell proliferation, migration, and invasion. In human keratinocytes infected with HPV, decreased levels of miR-34a-5p are associated with increased expression of its target JAG1 and enhanced activation of the Notch1 signaling cascade. Restoration of miR-34a-5p expression leads to inhibited cell development, underscoring its role in curbing HPV-driven cellular changes and emphasizing its impact on the Notch1 pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cervical cancer, reduced miR-34a expression correlates with a more aggressive disease phenotype and poorer patient survival. Quantitative analyses reveal that lower levels of this miRNA in cervical squamous cell carcinoma tissues serve as an independent prognostic indicator, suggesting that MIR34AHG’s regulatory product, miR-34a, might serve not only as a biomarker for diagnosis but also as a potential target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPreliminary data in mantle cell lymphoma further point to the functional relevance of miR-34a in hematologic malignancies. Efforts to elucidate its relationships with clinicopathological features and patient prognosis in MCL imply that alterations in MIR34AHG expression could contribute to disease progression and outcome, reinforcing the broad tumor-suppressive role of its mature miRNA product across diverse cancer types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ying Gao, Ming Yang, Liuliu Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-34a-5p Inhibits Cell Proliferation, Migration and Invasion Through Targeting JAG1/Notch1 Pathway in HPV-Infected Human Epidermal Keratinocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12253-019-00782-2"}], "href": "https://doi.org/10.1007/s12253-019-00782-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31781973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31781973"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Esra Bozgeyik, Neslihan Bayramoglu Tepe, Zehra Bozdag "}, {"type": "b", "children": [{"type": "t", "text": "Identification of microRNA expression signature for the diagnosis and prognosis of cervical squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2020.153159"}], "href": "https://doi.org/10.1016/j.prp.2020.153159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32841775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32841775"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianxia He, Yanfeng Xi, Ning Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of miRNA-34a and miRNA-155 as prognostic markers for mantle cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/03000605211016390"}], "href": "https://doi.org/10.1177/03000605211016390"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34024195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34024195"}]}]}]}