{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn lung adenocarcinoma (LUAD), miR-3529-5p acts as a critical tumor suppressor factor by directly targeting RNASEH2A, a gene implicated in cell proliferation, DNA replication, and genomic stability. High levels of RNASEH2A in LUAD cells correlate with enhanced proliferation and reduced apoptosis, and the binding of miR-3529-5p to its mRNA normally helps to keep these oncogenic processes in check. This regulatory interaction was identified via expression analyses, which revealed that decreased miR-3529-5p or its sequestration by competing RNAs can lead to the upregulation of RNASEH2A, thereby promoting tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "Furthermore, the study demonstrated that the long noncoding RNA LINC01287 competitively binds miR-3529-5p, effectively relieving the miRNA-mediated repression of RNASEH2A and contributing to LUAD progression. In addition, the transcription factor FOXA1 was shown to support this oncogenic axis by simultaneously upregulating both LINC01287 and RNASEH2A expression. Collectively, these findings highlight the pivotal role of miR-3529-5p within a regulatory network that controls cell proliferation and apoptosis in LUAD, suggesting that targeting this miRNA or its interacting partners might offer a promising therapeutic strategy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Zhang, Dan Ma, Honggang Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC01287 promotes proliferation and inhibits apoptosis of lung adenocarcinoma cells via the miR-3529-5p/RNASEH2A axis under the competitive endogenous RNA pattern."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/tox.23325"}], "href": "https://doi.org/10.1002/tox.23325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34254728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34254728"}]}]}]}