{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nStudies across a range of human malignancies demonstrate that the MIR361 family—comprising primarily the miR‑361‑3p and miR‑361‑5p isoforms—plays multifaceted roles in oncogenesis. In several solid tumors such as non‑small cell lung cancer, prostate cancer, cervical cancer, breast cancer, colorectal carcinoma, hepatocellular carcinoma, glioma, and retinoblastoma, MIR361 is frequently downregulated and acts as a tumor suppressor by targeting key oncogenes (for example, FOXM1, WT1, Twist1, YAP, and Sp1), thereby inhibiting cell proliferation, epithelial–mesenchymal transition (EMT), migration, invasion, and metastasis. In contrast, in certain contexts such as pancreatic ductal adenocarcinoma, overexpression of miR‑361‑3p can promote metastatic behaviors via enhancement of EMT and ERK signaling. Collectively, these findings underscore a context‑dependent regulatory role of MIR361 in cancer biology, with its aberrant expression correlating with poor clinical outcomes and suggesting potential applications as diagnostic and prognostic biomarkers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer, circulating levels of MIR361 have been implicated as useful biomarkers in non‑malignant conditions. In cardiovascular disease and coronary atherosclerosis, miR‑361‑5p can modulate angiogenesis by directly repressing vascular endothelial growth factor (VEGF) expression, while in diseases such as rheumatoid arthritis and cutaneous leishmaniasis, altered miR‑361 levels correlate with disease activity, treatment response, and healing time. Moreover, in osteoarthritis and late‑onset hypogonadism, deregulated plasma levels of MIR361 isoforms further reinforce their potential as non‑invasive diagnostic and prognostic indicators."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA number of studies have further elucidated the mechanisms modulating MIR361 activity. Several circular RNAs (circRNAs) and long non‑coding RNAs (lncRNAs) act as molecular “sponges” that sequester MIR361 isoforms and thereby impede their interaction with downstream mRNA targets. For instance, circRNA‑100146, circGFRA1, circ_0006089, and circ_0007813—as well as lncRNAs such as SBF2‑AS1, BBOX1‑AS1, MIR31HG, and NEAT1—have been shown to bind MIR361‑3p or MIR361‑5p in cancers of the lung, cervix, colon, bladder, and retinoblastoma, altering the expression of key regulators like ADAM19, TGFB1, EMP1, and OSR2. Such competitive endogenous RNA (ceRNA) interactions not only contribute to tumor progression and therapy resistance but also fine‑tune signaling pathways implicated in cell proliferation, apoptosis, and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carina Roth, Isabel Stückrath, Klaus Pantel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low levels of cell-free circulating miR-361-3p and miR-625* as blood-based markers for discriminating malignant from benign lung tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0038248"}], "href": "https://doi.org/10.1371/journal.pone.0038248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22675530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22675530"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Alexander Kanitz, Jochen Imig, Piotr J Dziunycz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0049568"}], "href": "https://doi.org/10.1371/journal.pone.0049568"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23166713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23166713"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Dachuang Liu, Tao Tao, Bin Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.01.140"}], "href": "https://doi.org/10.1016/j.bbrc.2014.01.140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24491557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24491557"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Feng Wang, Guangwen Long, Chunxia Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atherosclerosis-related circulating miRNAs as novel and sensitive predictors for acute myocardial infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0105734"}], "href": "https://doi.org/10.1371/journal.pone.0105734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25184815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25184815"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fei Ma, Hongjiang Song, Baoliang Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-361-5p inhibits colorectal and gastric cancer growth and metastasis by targeting staphylococcal nuclease domain containing-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3744"}], "href": "https://doi.org/10.18632/oncotarget.3744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25965817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25965817"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jian-Jun Sun, Guo-Yong Chen, Zhan-Tao Xie "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-361-5p Inhibits Cancer Cell Growth by Targeting CXCR6 in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000443033"}], "href": "https://doi.org/10.1159/000443033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26872014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26872014"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Wei Chen, Jun Wang, Sulai Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-016-0357-4"}], "href": "https://doi.org/10.1186/s13046-016-0357-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27164951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27164951"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shuxiang Yang, Yingchao Zhang, Xin Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-361 targets Wilms' tumor 1 to inhibit the growth, migration and invasion of non-small-cell lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2016.5858"}], "href": "https://doi.org/10.3892/mmr.2016.5858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27779659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27779659"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "X W Hou, X Sun, Y Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2017_406"}], "href": "https://doi.org/10.4149/neo_2017_406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28485158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28485158"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Suning Zhang, Zongang Liu, Lin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-361 targets Yes-associated protein (YAP) mRNA to suppress cell proliferation in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.08.072"}], "href": "https://doi.org/10.1016/j.bbrc.2017.08.072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28837805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28837805"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zhixin Ling, Dachuang Liu, Guangyuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-361-5p modulates metabolism and autophagy via the Sp1-mediated regulation of PKM2 in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5852"}], "href": "https://doi.org/10.3892/or.2017.5852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29094170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29094170"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Fei Ma, Lei Zhang, Li Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-361-5p inhibits glycolytic metabolism, proliferation and invasion of breast cancer by targeting FGFR1 and MMP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-017-0630-1"}], "href": "https://doi.org/10.1186/s13046-017-0630-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29132384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29132384"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jianjun Han, Jingjing Yu, Yu'na Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bosn J Basic Med Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17305/bjbms.2018.3399"}], "href": "https://doi.org/10.17305/bjbms.2018.3399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29924958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29924958"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jisheng Hu, Le Li, Hongze Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-361-3p regulates ERK1/2-induced EMT via DUSP2 mRNA degradation in pancreatic ductal adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0839-8"}], "href": "https://doi.org/10.1038/s41419-018-0839-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30042387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30042387"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Shikai Liu, Lili Song, Hairong Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preserved miR-361-3p Expression Is an Independent Prognostic Indicator of Favorable Survival in Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2018/8949606"}], "href": "https://doi.org/10.1155/2018/8949606"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30344797"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30344797"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Bin Shen, Ningfeng Zhou, Tao Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MEG3 negatively modified osteosarcoma development through regulation of miR-361-5p and FoxM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.28026"}], "href": "https://doi.org/10.1002/jcp.28026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30624782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30624782"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Bingqian Liu, Baiyang Lu, Xue Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-361-5p inhibits cell proliferation and induces cell apoptosis in retinoblastoma by negatively regulating CLDN8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Childs Nerv Syst (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00381-019-04199-9"}], "href": "https://doi.org/10.1007/s00381-019-04199-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31161266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31161266"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yangfei Ji, Dan Wang, Boai Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-361-3p inhibits β-amyloid accumulation and attenuates cognitive deficits through targeting BACE1 in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Integr Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31083/j.jin.2019.03.1136"}], "href": "https://doi.org/10.31083/j.jin.2019.03.1136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31601077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31601077"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Anying Wang, Naixia Hu, Yefeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MEG3 promotes proliferation and inhibits apoptosis in osteoarthritis chondrocytes by miR-361-5p/FOXO1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-019-0649-6"}], "href": "https://doi.org/10.1186/s12920-019-0649-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31888661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31888661"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Himiko Ogawa, Koh-Ichi Nakashiro, Norihiko Tokuzen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-361-3p is a potent therapeutic target for oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14359"}], "href": "https://doi.org/10.1111/cas.14359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32086979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32086979"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Daozhi Xu, Peixin Dong, Ying Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-361-Mediated Inhibition of HSP90 Expression and EMT in Cervical Cancer Is Counteracted by Oncogenic lncRNA NEAT1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9030632"}], "href": "https://doi.org/10.3390/cells9030632"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32151082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32151082"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Burhanettin Yalçınkaya, Esra Güzel, Didem Taştekin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of mir-33a, mir-203b, mir361-3p, and mir-424 in hepatocellular carcinoma"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Turk J Med Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3906/sag-2004-214"}], "href": "https://doi.org/10.3906/sag-2004-214"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33098283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33098283"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Liang-Chun Yin, Gang Xiao, Rui Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-361-5p Inhibits Tumorigenesis and the EMT of HCC by Targeting Twist1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2020/8891876"}], "href": "https://doi.org/10.1155/2020/8891876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33381597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33381597"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hsei-Wei Wang, Hung-Hao Lo, Ya-Lin Chiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulated miR-361-5p/VEGF axis in the plasma and endothelial progenitor cells of patients with coronary artery disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0098070"}], "href": "https://doi.org/10.1371/journal.pone.0098070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24865854"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24865854"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yao-Ping Chen, Ju Wang, Kai Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The plasma miR-125a, miR-361 and miR-133a are promising novel biomarkers for Late-Onset Hypogonadism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep23531"}], "href": "https://doi.org/10.1038/srep23531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27000524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27000524"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Xiaoping Zhang, Runxia Shao, Weiwei Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of miR-361-5p suppressed pulmonary artery smooth muscle cell survival and migration by targeting ABCA1 and inhibiting the JAK2/STAT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2018.01.015"}], "href": "https://doi.org/10.1016/j.yexcr.2018.01.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29339076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29339076"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Tainã S Lago, Juliana Almeida Silva, Ednaldo L Lago, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miRNA 361-3p, a Regulator of GZMB and TNF Is Associated With Therapeutic Failure and Longer Time Healing of Cutaneous Leishmaniasis Caused by "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "L. (viannia) braziliensis"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2018.02621"}], "href": "https://doi.org/10.3389/fimmu.2018.02621"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30487794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30487794"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "M F Romo-García, Y Bastian, M Zapata-Zuñiga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of putative miRNA biomarkers in early rheumatoid arthritis by genome-wide microarray profiling: A pilot study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2019.144081"}], "href": "https://doi.org/10.1016/j.gene.2019.144081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31473322"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31473322"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yunxia Tao, Jing Zhou, Zhen Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human bone mesenchymal stem cells-derived exosomal miRNA-361-5p alleviates osteoarthritis by downregulating DDX20 and inactivating the NF-κB signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioorg Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bioorg.2021.104978"}], "href": "https://doi.org/10.1016/j.bioorg.2021.104978"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34052737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34052737"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Lijian Chen, Aruo Nan, Nan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-0943-0"}], "href": "https://doi.org/10.1186/s12943-019-0943-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30665425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30665425"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Fangyuan Gao, Jing Feng, Hairong Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SBF2-AS1 promotes the progression of cervical cancer by regulating miR-361-5p/FOXM1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Artif Cells Nanomed Biotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21691401.2019.1577883"}], "href": "https://doi.org/10.1080/21691401.2019.1577883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30856345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30856345"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Xueyuan Yu, Xiangyu Liu, Rui Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA NEAT1 promotes the progression of hemangioma via the miR-361-5p/VEGFA pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.084"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.084"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30928097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30928097"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "C-Y Yang, F-X Zhang, J-N He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircRNA_100876 promote proliferation and metastasis of breast cancer cells through adsorbing microRNA-361-3p in a sponge form."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201908_18736"}], "href": "https://doi.org/10.26355/eurrev_201908_18736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31486496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31486496"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "W-X Lu "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA MEG3 represses cholangiocarcinoma by regulating miR-361-5p/TRAF3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201909_18842"}], "href": "https://doi.org/10.26355/eurrev_201909_18842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31539122"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31539122"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Jiasheng Liu, Jie Zhu, Zhe Xiao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BBOX1-AS1 contributes to colorectal cancer progression by sponging hsa-miR-361-3p and targeting SH2B1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Open Bio (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/2211-5463.12802"}], "href": "https://doi.org/10.1002/2211-5463.12802"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31984680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31984680"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Jun Xu, Baohua Yang, Lifeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA BBOX1-AS1 upregulates HOXC6 expression through miR-361-3p and HuR to drive cervical cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Prolif (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cpr.12823"}], "href": "https://doi.org/10.1111/cpr.12823"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32515533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32515533"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Yajing Li "}, {"type": "b", "children": [{"type": "t", "text": "MIR31HG exhibits oncogenic property and acts as a sponge for miR-361-3p in cervical carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.06.028"}], "href": "https://doi.org/10.1016/j.bbrc.2020.06.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32819595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32819595"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Yanhua Jiang, Fan Xiao, Lin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-020-03886-5"}], "href": "https://doi.org/10.1007/s11010-020-03886-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32844346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32844346"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "H Liu, H-F Yuan, D Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202012_23997"}], "href": "https://doi.org/10.26355/eurrev_202012_23997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33336726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33336726"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Shu-Rong Zheng, Qi-di Huang, Zhi-Hai Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circGFRA1 affects the sensitivity of triple-negative breast cancer cells to paclitaxel via the miR-361-5p/TLR4 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvaa148"}], "href": "https://doi.org/10.1093/jb/mvaa148"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33481008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33481008"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Peng Xu, XiaoLan Xu, Xiao Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircTMC5 promotes gastric cancer progression and metastasis by targeting miR-361-3p/RABL6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastric Cancer (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10120-021-01220-6"}], "href": "https://doi.org/10.1007/s10120-021-01220-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34296378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34296378"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Zheyu Zhang, Zezhong Mou, Chenyang Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04053-4"}], "href": "https://doi.org/10.1038/s41419-021-04053-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34365465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34365465"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Ying Zhou, Qilin Zhang, Bingling Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR-361-3p/TGFB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15351"}], "href": "https://doi.org/10.1111/cas.15351"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35347818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35347818"}]}]}]}