{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nTraumatic brain injury (TBI) has been increasingly linked to long‐term pituitary dysfunction, with circulating microRNAs (miRNAs) emerging as promising biomarkers for monitoring these pathological changes. Research has shown that, among hundreds of miRNAs analyzed in TBI patients, specific miRNAs such as miR‑126‑3p, miR‑3610, and miR‑3907 display consistent alterations in serum levels from the acute phase (Days 1, 7, and 28) to as long as 5 years post‑injury. These findings suggest that miR‑3610, in particular, may have a role in the pathogenesis of TBI‑induced hypopituitarism by serving as an indicator of the evolving neuroendocrine dysfunction following trauma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe longitudinal study demonstrated that miR‑3610 is reliably detected in the serum of patients who develop hypopituitarism after TBI. Its altered expression pattern over multiple time points hints at an involvement in the processes that underlie the neuroendocrine impairments seen in these patients. Such dynamic regulation underscores the potential of miR‑3610 not only as a diagnostic marker for early identification of pituitary dysregulation but also as a candidate for future therapeutic targeting aimed at mitigating TBI‑associated endocrine disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOverall, the consistent changes in miR‑3610 levels across both the acute phase and several years post‑injury emphasize its importance in the molecular signature of TBI‑induced hypopituitarism. Its measurement in the circulation could facilitate timely diagnosis and improve the understanding of the molecular mechanisms linking traumatic brain injury to long‑term pituitary dysfunction. These insights pave the way for developing miRNA‑based strategies to monitor and potentially intervene in the progression of neuroendocrine abnormalities following TBI."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Serpil Taheri, Fatih Tanriverdi, Gokmen Zararsiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating MicroRNAs as Potential Biomarkers for Traumatic Brain Injury-Induced Hypopituitarism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurotrauma (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/neu.2015.4281"}], "href": "https://doi.org/10.1089/neu.2015.4281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27027233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27027233"}]}]}]}