MIR3612 Gene

HGNC Family Non-coding RNAs
Name microRNA 3612
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn esophageal squamous cell carcinoma, miR-3612 has been identified as a tumor suppressor whose activity is compromised by its sequestration. In one study, the long noncoding RNA ZFPM2‐AS1 was found to function as an oncogene by sponging miR-3612, thereby relieving its suppression on TRAF4 and triggering the NF-κB pathway to promote cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn retinoblastoma, decreased levels of miR-3612—due to its binding by an overexpressed ZFPM2-AS1—led to the upregulation of NT5E, which in turn enhanced tumor cell proliferation and migration while reducing apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, in nasopharyngeal carcinoma, miR-3612 is also considered a tumor suppressor, although the precise underlying mechanisms in this cancer type remain to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUnder hypoxic conditions in esophageal cancer, the transcription factor HIF-1α upregulates the expression of the lncRNA LINC01116, which in turn acts as a competing endogenous RNA by sponging miR-3612. This downregulation of miR-3612 contributes to increased radioresistance, underscoring its critical role in modulating therapeutic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gaozhong Sun, Changhao Wu "}, {"type": "b", "children": [{"type": "t", "text": "ZFPM2-AS1 facilitates cell growth in esophageal squamous cell carcinoma via up-regulating TRAF4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20194352"}], "href": "https://doi.org/10.1042/BSR20194352"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32065218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32065218"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kui Ai, Wenchang Ni, Zhen Li "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA ZFPM2-AS1 Enhances Retinoblastoma Development by Targeting the miR-3612/NT5E Signaling Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2022042697"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022042697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35997119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35997119"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Zhang, Qiu Zhang, Qianbo Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Exp Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/09603271221150248"}], "href": "https://doi.org/10.1177/09603271221150248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36607163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36607163"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mengyan Zhang, Zhiping Wang, Yahua Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced factor-1α promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23551"}], "href": "https://doi.org/10.1002/jbt.23551"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37983895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37983895"}]}]}]}
NCBI Gene ID 100500817
API
Download Associations
Predicted Functions View MIR3612's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3612's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3612's ARCHS4 Predicted Functions.

Functional Associations

MIR3612 has 180 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3612 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3612 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3612 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3612 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3612 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3612 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3612 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3612 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR3612 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3612 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3612 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.