MIR3613 Gene

HGNC Family Non-coding RNAs
Name microRNA 3613
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In breast cancer, exosomal miR‐3613‑3p from carcinoma‐associated fibroblasts was shown to promote tumor cell proliferation and metastasis via suppression of SOCS2, suggesting an oncogenic role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In BRAFV600E‑mutant melanoma cells that have acquired resistance to Vemurafenib, re‐establishing miR‐3613‑3p expression downregulated CDC7 expression and reduced colony formation, thereby resensitizing cells to treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In pancreatic cancer, decreased miR‐3613‑5p levels in tumors correlated with poor survival and enhanced metastatic potential, with the miRNA acting as a tumor repressor by targeting CDK6."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in esophageal carcinoma, regulatory interactions involving long noncoding RNA BBOX1‑AS1 modulate miR‐3613‑3p levels to affect COL5A1 expression and influence cell proliferation and apoptosis, a mechanism that may extend to colorectal cancer through the TGF‑β/SMAD signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn neuroblastoma, the regulation of miR‐3613‑3p is also critical. Overexpression of miR‐3613‑3p was found to significantly downregulate several tumor suppressor genes—including APAF1, Dicer, DFFA, VHL, and NF1—resulting in decreased caspase activation and impaired apoptosis, thereby potentially favoring tumor cell survival. Moreover, studies indicate that the ribonuclease protein MCPIP1 modulates the abundance of miR‐3613‑3p through cleavage of its precursor, linking miR‐3613‑3p homeostasis to neuroblastoma cell viability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond cancer, miR‐3613‑3p plays a role in regulating stress responses and pathological tissue remodeling. In hypertrophic scar fibroblasts, downregulation of miR‐3613‑3p is associated with increased expression of ARGLU1 and excessive extracellular matrix production, while its overexpression inhibits cell proliferation and promotes apoptosis, suggesting its potential as a therapeutic target in fibrosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In endothelial cells exposed to heat stress, reduced miR‐3613‑3p levels result in diminished repression of MAP3K2, leading to activation of the downstream p38 and caspase‑3/‑9 pathways and consequently promoting apoptosis; restoration of miR‐3613‑3p protects cells from stress‐induced cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yonglei Liu, Yanfei Yang, Junxian Du, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Analysis of potential functional significance of microRNA‑3613‑3p in human umbilical vein endothelial cells affected by heat stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10376"}], "href": "https://doi.org/10.3892/mmr.2019.10376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31257536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31257536"}]}]}]}
NCBI Gene ID 100500908
API
Download Associations
Predicted Functions View MIR3613's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3613's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3613's ARCHS4 Predicted Functions.

Functional Associations

MIR3613 has 1,253 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3613 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3613 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3613 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3613 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3613 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3613 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR3613 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3613 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3613 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3613 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3613 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.