{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent genome‐wide association analyses have implicated miR-3614-5p in immune regulation, as a Crohn’s disease risk single nucleotide polymorphism (rs3853824) was found to alter its expression. This finding suggests that miR-3614 may contribute to autoimmunity by modulating downstream target genes in immune cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in immune pathways, a novel regulatory circuit involving miR-3614-3p was recently described. The study demonstrated that miR-3614-3p functions in concert with the RNA-binding protein IGF2BP3 to antagonistically regulate TRIM25 expression, thereby influencing posttranscriptional gene modulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of oncogenesis, miR-3614-5p has emerged as an important tumor suppressor in non-small cell lung cancer. It directly targets the 3’ untranslated region of PGAM1, a key enzyme in glycolysis whose expression is associated with tumor progression, resulting in reduced proliferation and invasion of cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in human prostate cancer, miR-3614-5p exerts potent antitumor effects through downregulation of the anti-apoptotic protein Mcl-1. By decreasing Mcl-1 expression, this miRNA promotes cell cycle arrest and apoptosis, further highlighting its role as a negative regulator of tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Inken Wohlers, Lars Bertram, Christina M Lill "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for a potential role of miR-1908-5p and miR-3614-5p in autoimmune disease risk using integrative bioinformatics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Autoimmun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaut.2018.07.010"}], "href": "https://doi.org/10.1016/j.jaut.2018.07.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30143393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30143393"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhenzhen Wang, Dongdong Tong, Cong Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EBioMedicine (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ebiom.2018.12.061"}], "href": "https://doi.org/10.1016/j.ebiom.2018.12.061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30797711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30797711"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fangfang Li, Hao Yang, Tiandong Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PGAM1, regulated by miR-3614-5p, functions as an oncogene by activating transforming growth factor-β (TGF-β) signaling in the progression of non-small cell lung carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02900-4"}], "href": "https://doi.org/10.1038/s41419-020-02900-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32855383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32855383"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yi-Hsien Hsieh, Fang-Jung Yu, Yasser Nassef, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting of Mcl-1 Expression by MiRNA-3614-5p Promotes Cell Apoptosis of Human Prostate Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23084194"}], "href": "https://doi.org/10.3390/ijms23084194"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35457012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35457012"}]}]}]}