{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR‐363 (encompassing both the 3p and 5p species) plays important roles in normal cell and tissue differentiation. For example, during human placental trophoblast differentiation the miR‐106a∼363 cluster is downregulated in concert with the induction of key differentiation markers, and aberrant regulation of these miRNAs disrupts syncytiotrophoblast formation. In adipose‐derived stromal cells, overexpression of miR‐363 markedly impairs mitotic clonal expansion by targeting the transcription factor E2F3, thereby blunting terminal adipocyte differentiation. Moreover, in the bone marrow microenvironment miR‐363–5p regulates the expression of angiocrine factors that modulate endothelial tube formation and hematopoietic precursor adhesion; additional studies even implicate miR‐363 in the specification of cardiomyocyte subtypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn numerous malignancies the predominant function of miR‐363–3p (and in several settings, miR‐363–5p) is tumor suppressive through direct targeting of key oncogenic mediators. In hepatocellular, renal, colorectal, endometrial and lung cancers, miR‐363–3p suppresses oncogenic signaling by directly reducing expression of factors such as USP28, MCL‐1, S1PR1, CREB1, NOTCH1, PCNA, SP1, SphK2 and HMGA2—actions that collectively block cell proliferation, migration, invasion and chemoresistance. In colon cancer, miR‐363 targeting of GATA6 mediates downstream repression of REG4, while in breast and cervical tumors, diminished exosomal miR‐363–5p is emerging as a promising biomarker for lymph node metastasis and poor prognosis. In addition, miR‐363 levels and activity are frequently modulated by a network of long noncoding RNAs (for example, MALAT1, FOXD2‐AS1, NNT‐AS1, OIP5‐AS1, HNF1A‐AS1 and NORAD) that act as endogenous sponges to fine tune its availability and, consequently, its tumor‐suppressive outputs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "30"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInterestingly, miR‐363 can also exhibit oncogenic (oncomiR) properties in a context‐dependent manner. Certain studies in gastric cancer have reported that elevated miR‐363 levels promote tumorigenesis by targeting tumor suppressors such as MBP‐1 and FBW7. Similar pro‐oncogenic roles have been observed in subsets of head and neck cancers associated with human papillomavirus, in glioma where miR‐363 overexpression correlates with higher tumor grade and enhanced cell survival, and in T‑cell acute lymphoblastic leukemia where miR‐363–3p supports proliferation by repressing PTEN and BIM. In melanoma, induction of miR‐363–3p by hypoxia‐inducible factors enhances cellular stemness via suppression of p21, further underscoring the dualistic, context‐dependent nature of miR‐363 in cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "31", "end_ref": "37"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Premlata Kumar, Yanmin Luo, Carmen Tudela, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A c-Myc-MicroRNA functional feedback loop affects hepatocarcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26302"}], "href": "https://doi.org/10.1002/hep.26302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23389829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23389829"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ruiguang Zhang, Yan Li, Xiaochuan Dong, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "REG4 is a transcriptional target of GATA6 and is essential for colorectal tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep14291"}], "href": "https://doi.org/10.1038/srep14291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26387746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26387746"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Bo Song, Jin Yan, Chao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor Suppressor Role of miR-363-3p in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.896556"}], "href": "https://doi.org/10.12659/msm.896556"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26709677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26709677"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yifan Li, Duqun Chen, Yuchi Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NR2F1-AS1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR-363."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13605"}], "href": "https://doi.org/10.1111/jcmm.13605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29602203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29602203"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jinlang Dong, Jianshan Geng, Weiwei Tan "}, {"type": "b", "children": [{"type": "t", "text": "MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.06.052"}], "href": "https://doi.org/10.1016/j.biopha.2018.06.052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30021386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30021386"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xin Wang, Mudan Ren, Yarui Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA NNT-AS1 promotes gastric cancer proliferation and invasion by regulating microRNA-363 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27855"}], "href": "https://doi.org/10.1002/jcb.27855"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30324628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30324628"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jing Wang, Huimin Liang, Haize Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑363‑3p inhibits hepatocarcinogenesis by targeting HMGA2 and is associated with liver cancer stage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9711"}], "href": "https://doi.org/10.3892/mmr.2018.9711"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30535489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30535489"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Fan He, Long Fang, Qingshui Yin "}, {"type": "b", "children": [{"type": "t", "text": "miR-363 acts as a tumor suppressor in osteosarcoma cells by inhibiting PDZD2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2019.7078"}], "href": "https://doi.org/10.3892/or.2019.7078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30896877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30896877"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yi Pan, Xue Zhu, Ke Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-363-3p suppresses anoikis resistance in human papillary thyroid carcinoma via targeting integrin alpha 6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmz066"}], "href": "https://doi.org/10.1093/abbs/gmz066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31257410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31257410"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jingxia Chang, Feng Gao, Heying Chu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA OIP5-AS1 interacts with miR-363-3p to contribute to hepatocellular carcinoma progression through up-regulation of SOX4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41434-020-0123-2"}], "href": "https://doi.org/10.1038/s41434-020-0123-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32042127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32042127"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yongyan Bi, Yuhang Mao, Zuopeng Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA HNF1A-AS1 regulates proliferation and apoptosis of glioma through activation of the JNK signaling pathway via miR-363-3p/MAP2K4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29916"}], "href": "https://doi.org/10.1002/jcp.29916"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32779194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32779194"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Qianqian Geng, Zhubin Li, Xintao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA NORAD, sponging miR-363-3p, promotes invasion and EMT by upregulating PEAK1 and activating the ERK signaling pathway in NSCLC cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-021-09892-6"}], "href": "https://doi.org/10.1007/s10863-021-09892-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33742335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33742335"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Hyun Park, Mi-jung Lee, Ju-yeon Jeong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulated microRNA expression in adenocarcinoma of the uterine cervix: clinical impact of miR-363-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2014.09.010"}], "href": "https://doi.org/10.1016/j.ygyno.2014.09.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25230213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25230213"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "F Pan, H Xiang, J Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dendritic Cells from Rheumatoid Arthritis Patient Peripheral Blood Induce Th17 Cell Differentiation via miR-363/Integrin αv/TGF-β Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/sji.12550"}], "href": "https://doi.org/10.1111/sji.12550"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28376277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28376277"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Mingyi Li, Ruolan Luo, Wenjian Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-363-3p is activated by MYB and regulates osteoporosis pathogenesis via PTEN/PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "In Vitro Cell Dev Biol Anim (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11626-019-00344-5"}], "href": "https://doi.org/10.1007/s11626-019-00344-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31025251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31025251"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Kai-Wen Hsu, An-Ming Wang, Yueh-Hsin Ping, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgt285"}], "href": "https://doi.org/10.1093/carcin/bgt285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23975832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23975832"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Bhavana V Chapman, Abigail I Wald, Parvez Akhtar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-015-1888-3"}], "href": "https://doi.org/10.1186/s12885-015-1888-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26545583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26545583"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Peng-Fei Zhang, Lu-Lu Sheng, Ge Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-363 promotes proliferation and chemo-resistance of human gastric cancer via targeting of FBW7 ubiquitin ligase expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9169"}], "href": "https://doi.org/10.18632/oncotarget.9169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27167197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27167197"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Alfredo Conti, Sara G Romeo, Annamaria Cama, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-363-3p/p21(Cip1/Waf1) axis is regulated by HIF-2α in mediating stemness of melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2018_180828N655"}], "href": "https://doi.org/10.4149/neo_2018_180828N655"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30784290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30784290"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Monika Drobna, Bronisława Szarzyńska, Roman Jaksik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hsa-miR-20b-5p and hsa-miR-363-3p Affect Expression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PTEN"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "BIM"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Tumor Suppressor Genes and Modulate Survival of T-ALL Cells In Vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9051137"}], "href": "https://doi.org/10.3390/cells9051137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32380791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32380791"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Yongtao Zhang, Fang Wang, Lina Wang, et al. 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