{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified miR‑3646 as an important regulator in cardiovascular disorders. In patients with acute coronary syndrome, miR‑3646 is markedly upregulated compared with healthy controls, and its expression level correlates with disease severity. Experimental models demonstrated that silencing miR‑3646 alleviates the inflammatory response associated with acute coronary events, indicating that this miRNA may serve as both a valuable diagnostic biomarker and a potential therapeutic target in these conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of miR‑3646 has also been reported in lung adenocarcinoma. In this setting, elevated miR‑3646 levels were found to promote malignant cellular behaviors by enhancing cell proliferation and adhesion while reducing apoptosis. Mechanistic investigations revealed that miR‑3646 directly targets the gene SORBS1, leading to disruption of the JNK signaling pathway—a process that appears to drive tumor progression. These findings suggest that miR‑3646 contributes to lung cancer pathogenesis and may offer a novel target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in acute coronary syndrome and lung adenocarcinoma, miR‑3646 has been implicated in modulating the inflammatory response of vascular smooth muscle cells. Studies on angiotensin II–induced human vascular smooth muscle cells indicate that upregulation of miR‑3646 is associated with increased inflammatory signaling, which may contribute to the development and progression of hypertension and coronary artery disease. This further underscores the broad impact of miR‑3646 on cardiovascular pathophysiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinming Yu, Yongmei Li, Deguo Leng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-3646 serves as a diagnostic marker and mediates the inflammatory response induced by acute coronary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1967066"}], "href": "https://doi.org/10.1080/21655979.2021.1967066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34519257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34519257"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chun Wang, Bo Cheng "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-3646 promotes malignancy of lung adenocarcinoma cells by suppressing sorbin and SH3 domain-containing protein 1 via the c-Jun NH2-terminal kinase signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2036889"}], "href": "https://doi.org/10.1080/21655979.2022.2036889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35196185"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35196185"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Runzhi Liu, Liying Zhong, Cong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3646 accelerates inflammatory response of Ang II-induced hVSMCs via CYP2J2/EETs axis in hypertension model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Hypertens (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10641963.2023.2166948"}], "href": "https://doi.org/10.1080/10641963.2023.2166948"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36751048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36751048"}]}]}]}