MIR3648-1 Gene

HGNC Family Non-coding RNAs
Name microRNA 3648-1
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR3648 is a human‐specific microRNA that modulates cell proliferation by targeting key tumor suppressors. Under endoplasmic reticulum stress, MIR3648 is induced and directly downregulates APC2, a negative regulator of the Wnt/β‑catenin signaling pathway, leading to increased cell proliferation. In prostate cancer, its overexpression similarly suppresses APC2 and promotes cell cycle progression via upregulation of cyclin D1 and cyclin E1 while inhibiting p21 expression, thereby enhancing tumor cell growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn gastric cancer, MIR3648 appears to function as a tumor suppressor. Its ectopic expression significantly inhibits cell proliferation and metastasis by directly targeting FRAT1 and FRAT2, which in turn inactivates the Wnt/β‑catenin pathway and reduces the expression of its downstream effector, c-Myc. Notably, c-Myc can negatively regulate MIR3648 expression through promoter binding, establishing a critical negative feedback loop in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn lung adenocarcinoma, MIR3648 is overexpressed and exerts oncogenic effects by binding to and suppressing SOCS2, which facilitates enhanced cell proliferation, migration, and invasion. Although these results highlight the importance of MIR3648 in lung adenocarcinoma progression, its exact clinical significance in non‐small cell lung cancer remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Farooq Rashid, Hassaan Mehboob Awan, Abdullah Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms18071375"}], "href": "https://doi.org/10.3390/ijms18071375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28661420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28661420"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rongwei Xing "}, {"type": "b", "children": [{"type": "t", "text": "miR-3648 Promotes Prostate Cancer Cell Proliferation by Inhibiting Adenomatous Polyposis Coli 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nanosci Nanotechnol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1166/jnn.2019.16413"}], "href": "https://doi.org/10.1166/jnn.2019.16413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31196256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31196256"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weimei Tang, Miaomiao Pei, Jiaying Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-022-02451-2"}], "href": "https://doi.org/10.1038/s41388-022-02451-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36153370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36153370"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yanhong Tu, Fan Mei "}, {"type": "b", "children": [{"type": "t", "text": "miR-3648 promotes lung adenocarcinoma-genesis by inhibiting SOCS2 (suppressor of cytokine signaling 2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2017577"}], "href": "https://doi.org/10.1080/21655979.2021.2017577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35037826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35037826"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yongquan Dong, Biao Wu, Xiongxiong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High miR-3648 expression and low APC2 expression are associated with shorter survival and tumor progression in NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histol Histopathol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14670/HH-18-411"}], "href": "https://doi.org/10.14670/HH-18-411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34927228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34927228"}]}]}]}
Synonyms MIR3648, HSA-MIR-3648-1
NCBI Gene ID 100500862
API
Download Associations
Predicted Functions View MIR3648-1's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3648-1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3648-1's ARCHS4 Predicted Functions.

Functional Associations

MIR3648-1 has 1,696 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 8 datasets.

Click the + buttons to view associations for MIR3648-1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3648-1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3648-1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3648-1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR3648-1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of MIR3648-1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3648-1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3648-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3648-1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.