{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn patients with oral squamous cell carcinoma (OSCC), aberrant expression of specific microRNAs in whole blood samples has been proposed as a minimally invasive diagnostic tool. Notably, miR‑3651 is found to be significantly upregulated—approximately two‐fold—in OSCC patients compared to healthy controls. Furthermore, the overexpression of miR‑3651 shows significant correlations with key clinicopathological features such as lymph node status, tumor grade, and overall clinical stage. These findings suggest that miR‑3651 could serve as an informative biomarker for early detection and prognostic assessment in OSCC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jerome E Roger, Avinash Hiriyanna, Norimoto Gotoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI72722"}], "href": "https://doi.org/10.1172/JCI72722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24382353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24382353"}]}]}]}