| HGNC Family | Non-coding RNAs |
| Name | microRNA 3658 |
| Description | microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHsa‐miR-3658 has been implicated in the dysregulation of various tumors. In bladder cancer, evidence indicates that miR-3658 is significantly upregulated relative to adjacent non-tumor tissues, and its overexpression correlates with aggressive clinicopathological features—including lymph node invasion, distant metastasis, high histological grade, advanced TNM stage, and tumor recurrence. These findings suggest that miR-3658 may serve as a valuable prognostic biomarker in bladder cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, studies of colorectal cancer reveal that miR-3658 is downregulated in tumor tissues relative to normal controls, and its elevated expression leads to the suppression of the pluripotency marker OCT4 through direct binding to its 3′-untranslated region. This downregulation of OCT4 is associated with growth inhibition, cell cycle arrest, and reduced cell migration, underscoring the tumor-suppressive role of miR-3658 and its potential as both a prognostic marker and therapeutic target in colorectal cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Y J Chen, H F Wang, M Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of miR-3658 in bladder cancer and tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/gmr15049048"}], "href": "https://doi.org/10.4238/gmr15049048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27820650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27820650"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ting Luan, Renchao Zou, Lijuan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-miR-3658 Promotes Cell Proliferation, Migration and Invasion by Effecting LASS2 in Bladder Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Lab (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7754/Clin.Lab.2017.171026"}], "href": "https://doi.org/10.7754/Clin.Lab.2017.171026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29739079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29739079"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Fahimeh Hosseini, Bahram M Soltani, Hossein Baharvand, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa-miR-3658 down-regulates OCT4 gene expression followed by suppressing SW480 cell proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20190619"}], "href": "https://doi.org/10.1042/BCJ20190619"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32478824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32478824"}]}]}]}
|
| NCBI Gene ID | 100500832 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
MIR3658 has 359 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 11 datasets.
Click the + buttons to view associations for MIR3658 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR3658 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR3658 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR3658 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3658 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MIR3658 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MIR3658 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MIR3658 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MIR3658 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MIR3658 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MIR3658 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| WikiPathways Pathways 2014 | pathways involving MIR3658 protein from the Wikipathways Pathways 2014 dataset. | |
