{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into the molecular mechanisms underlying metabolic abnormalities have implicated MIR3659 as a regulatory miRNA associated with dyslipidemia in obese individuals. In this context, altered levels of MIR3659 appear to influence gene expression networks that modulate lipid metabolism and energy balance, providing novel insights into the pathogenesis of obesity‐related dyslipidemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "In the realm of liver cancer research, transcriptomic profiling has identified a spectrum of noncoding RNAs—including MIR3659—that may drive the heterogeneous progression of hepatocellular carcinoma. The deregulation of MIR3659 in hepatocellular carcinoma suggests it could be instrumental in modulating oncogenic pathways, thereby contributing to the tumor’s diverse phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "Furthermore, emerging diagnostic strategies for prostate cancer have leveraged biofluid-based measurements of tumor microRNAs. Notably, the urinary ratio involving hsv2-miR-H9 and hsa-miR-3659 has been evaluated for its efficacy as a non-invasive biomarker for prostate cancer detection, underscoring MIR3659’s potential clinical utility in cancer diagnostics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Liu Miao, Rui-Xing Yin, Shang-Ling Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-019-1776-8"}], "href": "https://doi.org/10.1186/s12967-019-1776-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30642348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30642348"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ji-Hye Choi, So M Kwon, Sung U Moon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TPRG1-AS1 induces RBM24 expression and inhibits liver cancer progression by sponging miR-4691-5p and miR-3659."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Liver Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/liv.15026"}], "href": "https://doi.org/10.1111/liv.15026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34328265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34328265"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ho Won Kang, Young Joon Byun, Sung Min Moon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urinary hsv2-miR-H9 to hsa-miR-3659 ratio is an effective marker for discriminating prostate cancer from benign prostate hyperplasia in patients within the prostate-specific antigen grey zone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Investig Clin Urol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4111/icu.20210493"}], "href": "https://doi.org/10.4111/icu.20210493"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35244999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35244999"}]}]}]}