MIR365B Gene

HGNC Family Non-coding RNAs
Name microRNA 365b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR365B is a multifunctional microRNA whose dysregulation has been linked to a broad spectrum of diseases. In one study evaluating cardiovascular health in children, altered plasma miRNA levels—including MIR365B—were associated with endothelial dysfunction, highlighting its potential as a novel biomarker in multifactorial disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hematological malignancies, MIR365B appears as part of a unique miRNA signature; one report identified the up‐regulation of the miR-193b-365 cluster in multiple myeloma, while further functional analysis demonstrated that MIR365B can suppress tumor cell proliferation and invasion by targeting key regulators such as HOXA9 (and thereby reducing xenograft tumor growth)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cancers of the central nervous system and lung, MIR365B generally acts as a tumor suppressor. In glioma, its strong downregulation leads to the upregulation of targets like PIK3R3 and enhanced AKT/mTOR signaling, which in turn promotes cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In non‐small cell lung cancer (NSCLC), decreased MIR365B levels correlate with aggressive tumor behavior and poor clinical outcome, whereas its restoration increases radiosensitivity through direct targeting of cell cycle regulators such as CDC25A and suppression of thyroid transcription factor‐1 (TTF-1)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": " Moreover, studies addressing NSCLC with bone metastasis further support a role for MIR365B in modulating invasion and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several other solid tumors, the role of MIR365B is nuanced and context‐dependent. In hepatocellular carcinoma (HCC), contrasting findings have emerged: one report documents decreased MIR365B levels associated with tumor suppression and favorable prognosis (indicating a tumor‐suppressive role), whereas another study on an isoform termed MIR365b demonstrates that its overexpression promotes cell motility and invasion by targeting SGTB (suggesting an oncogenic function)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In breast cancer, elevated MIR365B correlates with advanced clinical stage through downregulation of ADAMTS‐1, functioning as an oncogene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Likewise, in cervical cancer, decreased MIR365B expression relieves its inhibitory effect on ELF4, thereby fostering cell proliferation and tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Finally, early investigations in Alzheimer’s disease suggest that MIR365B, along with other microRNAs, may participate in underlying pathogenic processes, although its precise mechanistic role remains to be elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Abdelnaby Khalyfa, Leila Kheirandish-Gozal, Rakesh Bhattacharjee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating microRNAs as Potential Biomarkers of Endothelial Dysfunction in Obese Children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1378/chest.15-0799"}], "href": "https://doi.org/10.1378/chest.15-0799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26270249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26270249"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kenji Unno, Ying Zhou, Todd Zimmerman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel microRNA cluster miR-193b-365 in multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/10428190903221010"}], "href": "https://doi.org/10.3109/10428190903221010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19883314"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19883314"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Zhao, Wei-Wei Shen, Xiao-Mei Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mechanism of miRNA-365-regulated trophoblast apoptosis in recurrent miscarriage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13163"}], "href": "https://doi.org/10.1111/jcmm.13163"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28393453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28393453"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ying Gao, Yudi Miao, Weihua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-365 induces apoptosis and inhibits invasion of human myeloma cells by targeting homeobox A9 (HOXA9)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Toxicol Pharmacol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.etap.2021.103627"}], "href": "https://doi.org/10.1016/j.etap.2021.103627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33621688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33621688"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yonggang Zhu, Hongguang Zhao, Min Rao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5458"}], "href": "https://doi.org/10.3892/or.2017.5458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28260020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28260020"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hang Li, Mian Jiang, Ming Cui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-365 enhances the radiosensitivity of non-small cell lung cancer cells through targeting CDC25A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.082"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30902389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30902389"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Juanjuan Bai, Zhongling Zhang, Xing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-365 inhibits growth, invasion and metastasis of malignant melanoma by targeting NRP1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26191184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26191184"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yanyan Liu, Guoxiu Zhang, Haiyan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum microRNA-365 in combination with its target gene TTF-1 as a non-invasive prognostic marker for non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2015.07.026"}], "href": "https://doi.org/10.1016/j.biopha.2015.07.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26337230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26337230"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ruifang Sun, Zhigang Liu, Gang Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations of deregulation of mir-365 and its target mRNA TTF-1 and survival in patients with NSCLC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26045746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26045746"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yanyan Liu, Junmei Jia, Bin Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum microRNA-365 suppresses non-small-cell lung cancer metastasis and invasion in patients with bone metastasis of lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0300060520939718"}], "href": "https://doi.org/10.1177/0300060520939718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33121309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33121309"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Zhizhao Chen, Zufa Huang, Qifa Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance and anti-proliferation effect of microRNA-365 in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25973057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25973057"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qi Tian, He-Fen Sun, Wen-Jing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miRNA-365b promotes hepatocellular carcinoma cell migration and invasion by downregulating "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SGTB"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2018-0676"}], "href": "https://doi.org/10.2217/fon-2018-0676"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30943053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30943053"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Min Li, Lulu Liu, Wenqiao Zang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2015.3015"}], "href": "https://doi.org/10.3892/ijo.2015.3015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25998153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25998153"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ying Guo, Dong Ma, Shi Feng Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Proliferation of MicroRNA-365 and E74-like Factor 4 in Cervical Cancer Cells and Its Clinical Significance]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3881/j.issn.1000-503X.10613"}], "href": "https://doi.org/10.3881/j.issn.1000-503X.10613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31060678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31060678"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yuye Wang, Shuang Lv, Xiao Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of hsa-miR-365b-5p's role in Alzheimer's disease: A combined analysis of miRNA and mRNA microarrays."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2022.136892"}], "href": "https://doi.org/10.1016/j.neulet.2022.136892"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36181964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36181964"}]}]}]}
Synonyms MIR-365B, HSA-MIR-365B, MIRN365-2, MIR365-2
NCBI Gene ID 100126356
API
Download Associations
Predicted Functions View MIR365B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR365B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR365B's ARCHS4 Predicted Functions.

Functional Associations

MIR365B has 291 functional associations with biological entities spanning 4 categories (molecular profile, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR365B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR365B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR365B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR365B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR365B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR365B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR365B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR365B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing MIR365B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR365B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of MIR365B gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR365B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR365B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR365B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR365B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.