MIR3663 Gene

HGNC Family Non-coding RNAs
Name microRNA 3663
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have begun to elucidate the role of miR-3663‐3p as a regulator of gene expression in cancer progression. In papillary thyroid cancer, for example, miR-3663-3p has been implicated in controlling cell proliferation, invasion, and apoptosis through its modulation by the long noncoding RNA RPL34-AS1. Overexpression of RPL34-AS1 in thyroid cancer cell lines was found to suppress proliferation and invasion while inducing apoptosis by acting as a “sponge” for miR-3663-3p, thereby regulating expression of RGS4 and ultimately influencing tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate investigation in gastric cancer, the function of miR-3663-3p was further examined in the context of its contribution to the regulation of oncogenic pathways. Although the precise downstream targets and mechanisms remain to be fully characterized, the findings suggest that miR-3663-3p plays an important role in modulating gene expression patterns that drive cancer progression, making it a potential biomarker and therapeutic target in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lili Ji, Xing Fan, Feng Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29256"}], "href": "https://doi.org/10.1002/jcp.29256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31587286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31587286"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Koji Takao, Hirotaka Konishi, Daiki Matsubara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3663-3p Inhibits the Progression of Gastric Cancer Through the CCND1 Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21873/anticanres.15019"}], "href": "https://doi.org/10.21873/anticanres.15019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33952469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33952469"}]}]}]}
NCBI Gene ID 100500893
API
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Predicted Functions View MIR3663's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3663's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3663's ARCHS4 Predicted Functions.

Functional Associations

MIR3663 has 751 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3663 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3663 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3663 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3663 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3663 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3663 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3663 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3663 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3663 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of MIR3663 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3663 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.