{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query requests a summary of the function of MIR3665, a careful review of the provided abstracts reveals that none of them mention or characterize MIR3665. Instead, the collection of studies overwhelmingly focuses on the roles and regulatory networks of the basic helix‐loop‐helix transcription factor TWIST1. TWIST1 is shown to drive the epithelial–mesenchymal transition (EMT) during both development and tumor progression by repressing epithelial markers (for example, E‐cadherin) and inducing mesenchymal gene expression. Its activity is linked to processes such as cell migration, invasion, metastasis, and even the maintenance of stem cell–like properties in cancer cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther studies in the set extensively detail TWIST1’s involvement in developmental processes and tissue homeostasis. In particular, TWIST1 is implicated in craniofacial morphogenesis, the regulation of cytokine signaling, and the maintenance of the balance between mesenchymal proliferation and differentiation. TWIST1 functions via interactions with co-factors and signaling pathways such as NF-κB, STAT3, FGFR2, and components of the Mi2/NuRD complex, thereby affecting inflammatory responses and the proper formation of structures including cranial sutures and limb elements."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOther reports further connect TWIST1 activity to oncogenic processes such as resistance to chemotherapeutic agents and the promotion of cancer stem cell–related traits via multiple signaling “axes” (for instance, the STAT3–TWIST1–AKT2 pathway), as well as to the regulation of endothelial–mesenchymal transition (EndMT) in cardiovascular pathologies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn sum, while these studies provide an in‐depth characterization of TWIST1—as a master regulator of EMT, metastasis, developmental patterning, and various cell signaling cascades—the function of MIR3665 remains unaddressed. There is no evidence in the supplied literature linking MIR3665 to these or any other processes; hence, any role for MIR3665 must await future investigation to determine whether it might intersect with TWIST1-regulated networks or operate in an independent pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "8"}, {"type": "fg_fs", "start_ref": "16", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Drazen Šošić, James A Richardson, Kai Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00002-3"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00002-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12553906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12553906"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jing Yang, Sendurai A Mani, Joana Liu Donaher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2004.06.006"}], "href": "https://doi.org/10.1016/j.cell.2004.06.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15210113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15210113"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Esmeralda Casas, Jihoon Kim, Andrés Bendesky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-10-2330"}], "href": "https://doi.org/10.1158/0008-5472.CAN-10-2330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21199805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21199805"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "George Z Cheng, Wei Zhou Zhang, Mei Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M707429200"}], "href": "https://doi.org/10.1074/jbc.M707429200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18353781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18353781"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Junjiang Fu, Li Qin, Tao He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2010.118"}], "href": "https://doi.org/10.1038/cr.2010.118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20714342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20714342"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "M Nusrat Sharif, Drazen Sosic, Carla V Rothlin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist mediates suppression of inflammation by type I IFNs and Axl."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20051725"}], "href": "https://doi.org/10.1084/jem.20051725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16831897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16831897"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kenneth Soo, Meredith P O'Rourke, Poh-Lynn Khoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/dbio.2002.0699"}], "href": "https://doi.org/10.1006/dbio.2002.0699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12086465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12086465"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Vikram P Sharma, Aimée L Fenwick, Mia S Brockop, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in TCF12, encoding a basic helix-loop-helix partner of TWIST1, are a frequent cause of coronal craniosynostosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2531"}], "href": "https://doi.org/10.1038/ng.2531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23354436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23354436"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Benjamin Beck, Gaëlle Lapouge, Sandrine Rorive, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Different levels of Twist1 regulate skin tumor initiation, stemness, and progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2014.12.002"}], "href": "https://doi.org/10.1016/j.stem.2014.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25575080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25575080"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jeannette Connerney, Viktoria Andreeva, Yael Leshem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist1 dimer selection regulates cranial suture patterning and fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.20717"}], "href": "https://doi.org/10.1002/dvdy.20717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16502419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16502419"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Eliah R Shamir, Elisa Pappalardo, Danielle M Jorgens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist1-induced dissemination preserves epithelial identity and requires E-cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201306088"}], "href": "https://doi.org/10.1083/jcb.201306088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24590176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24590176"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Keun-Woo Lee, So-Young Yeo, Chang Ohk Sung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist1 is a key regulator of cancer-associated fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-0350"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-0350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25368021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25368021"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yixiang Xu, Dong-Kee Lee, Zhen Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Breast tumor cell-specific knockout of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Twist1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " inhibits cancer cell plasticity, dissemination, and lung metastasis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1618091114"}], "href": "https://doi.org/10.1073/pnas.1618091114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29073077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29073077"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Hong-Jen Lee, Chien-Feng Li, Diane Ruan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The DNA Damage Transducer RNF8 Facilitates Cancer Chemoresistance and Progression through Twist Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2016.08.009"}], "href": "https://doi.org/10.1016/j.molcel.2016.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27618486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27618486"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Meredith P O'Rourke, Patrick P L Tam "}, {"type": "b", "children": [{"type": "t", "text": "Twist functions in mouse development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Dev Biol (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12141426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12141426"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Li Chen, Ruju Chen, Sherri Kemper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Gastrointest Liver Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpgi.00140.2015"}], "href": "https://doi.org/10.1152/ajpgi.00140.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26229009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26229009"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Marwa M Mahmoud, Hyejeong Rosemary Kim, Rouyu Xing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCRESAHA.116.308870"}], "href": "https://doi.org/10.1161/CIRCRESAHA.116.308870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27245171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27245171"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jeannette Connerney, Viktoria Andreeva, Yael Leshem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2008.03.037"}], "href": "https://doi.org/10.1016/j.ydbio.2008.03.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18471809"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18471809"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Veronika Pozharskaya, Edilson Torres-González, Mauricio Rojas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0007559"}], "href": "https://doi.org/10.1371/journal.pone.0007559"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19851501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19851501"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hichem Miraoui, Nicolas Severe, Pascal Vaudin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: implication of FGFR2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22628"}], "href": "https://doi.org/10.1002/jcb.22628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20564211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20564211"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Dayana Krawchuk, Shoshana J Weiner, You-Tzung Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist1 activity thresholds define multiple functions in limb development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2010.08.015"}], "href": "https://doi.org/10.1016/j.ydbio.2010.08.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20732316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20732316"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "L Henry Goodnough, Andrew T Chang, Charles Treloar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist1 mediates repression of chondrogenesis by β-catenin to promote cranial bone progenitor specification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.081679"}], "href": "https://doi.org/10.1242/dev.081679"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23095887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23095887"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ying Zhang, Mohammad Q Hassan, Zhao-Yong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intricate gene regulatory networks of helix-loop-helix (HLH) proteins support regulation of bone-tissue related genes during osteoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.21844"}], "href": "https://doi.org/10.1002/jcb.21844"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18655182"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18655182"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Aimée Zuniga, Renaud Quillet, Fabienne Perrin-Schmitt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Dev (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0925-4773(02)00048-5"}], "href": "https://doi.org/10.1016/s0925-4773(02"}, {"type": "t", "text": "00048-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12175489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12175489"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "S Demontis, C Rigo, S Piccinin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist is substrate for caspase cleavage and proteasome-mediated degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.cdd.4401744"}], "href": "https://doi.org/10.1038/sj.cdd.4401744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16096654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16096654"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wenli Yu, Harold Kamara, Kathy K H Svoboda "}, {"type": "b", "children": [{"type": "t", "text": "The role of twist during palate development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.21627"}], "href": "https://doi.org/10.1002/dvdy.21627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18697225"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18697225"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Duy Pham, Joshua W Vincentz, Anthony B Firulli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1200854"}], "href": "https://doi.org/10.4049/jimmunol.1200854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22685315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22685315"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "You-Tzung Chen, Peter O Akinwunmi, Jian Min Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Generation of a Twist1 conditional null allele in the mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genesis (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvg.20332"}], "href": "https://doi.org/10.1002/dvg.20332"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17868088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17868088"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Camilla S Teng, Man-Chun Ting, D'Juan T Farmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.37024"}], "href": "https://doi.org/10.7554/eLife.37024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30375332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30375332"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Hai-Yun Yen, Man-Chun Ting, Robert E Maxson "}, {"type": "b", "children": [{"type": "t", "text": "Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2010.08.010"}], "href": "https://doi.org/10.1016/j.ydbio.2010.08.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20727876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20727876"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Zilong Li, Baoyu Chen, Wenhui Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MKL1 promotes endothelial-to-mesenchymal transition and liver fibrosis by activating TWIST1 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-2101-4"}], "href": "https://doi.org/10.1038/s41419-019-2101-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31776330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31776330"}]}]}]}