MIR3666 Gene

HGNC Family Non-coding RNAs
Name microRNA 3666
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
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In thyroid carcinoma, although its role remains underexplored, altered expression suggests a possible involvement in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‐small cell lung cancer, miR‑3666 has been shown to target SIRT7, leading to inhibition of cell growth and induction of apoptosis, while similar SIRT7‐mediated anti‑oncogenic effects have been observed in breast cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther studies in colorectal cancer have indicated that miR‑3666 is implicated both in mediating the inhibitory effects of all‑trans retinoic acid and by directly targeting genes such as SATB2 to suppress tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In lung adenocarcinoma, miR‑3666 downregulates BPTF, thereby impeding cell proliferation, migration, and invasion"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and in glioblastoma, its overexpression has been linked to the targeting of KDM2A, resulting in cell cycle arrest and reduced malignant behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, miR‑3666 functions as a tumor suppressor that is itself regulated by non‑coding RNAs; for instance, circPVT1 acts as a molecular sponge to reduce miR‑3666 availability and promote SIRT7 expression, while LINC00839 negatively regulates miR‑3666, affecting cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Beyond cancer, miR‑3666 also negatively regulates PPARγ, thus being involved in the development of hepatic steatosis, and in ovarian carcinoma, it suppresses tumor growth by targeting the STAT3/AK4 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gang Wang, Chengzhong Cai, Lei Chen "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3666 Regulates Thyroid Carcinoma Cell Proliferation via MET."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000443054"}], "href": "https://doi.org/10.1159/000443054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26937629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26937629"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hongyang Shi, Yuqiang Ji, Dexin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3666-induced suppression of SIRT7 inhibits the growth of non-small cell lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5063"}], "href": "https://doi.org/10.3892/or.2016.5063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27599551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27599551"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Di Li, Lifei Li "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑3666 inhibits breast cancer cell proliferation by targeting sirtuin 7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7603"}], "href": "https://doi.org/10.3892/mmr.2017.7603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28944911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28944911"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Weihong Liu, Yanqiu Song, Chenggui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.05.015"}], "href": "https://doi.org/10.1016/j.biopha.2018.05.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29772445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29772445"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Daqing Yang, Rizeng Li, Jianfu Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑3666 suppresses cellular proliferation and invasion in colorectal cancer by targeting SATB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9540"}], "href": "https://doi.org/10.3892/mmr.2018.9540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30320357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30320357"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Linqing Pan, Zhipeng Tang, Lina Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3666 inhibits lung cancer cell proliferation, migration, and invasiveness by targeting BPTF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/bcb-2018-0301"}], "href": "https://doi.org/10.1139/bcb-2018-0301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30481052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30481052"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Taotao Shou, Huyin Yang, Jia Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑3666 suppresses the growth and migration of glioblastoma cells by targeting KDM2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2018.9698"}], "href": "https://doi.org/10.3892/mmr.2018.9698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30483744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30483744"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yong Li, Haitao Shi, Jia Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Pharmacol Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1440-1681.13273"}], "href": "https://doi.org/10.1111/1440-1681.13273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32017171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32017171"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "B Meng, F Han, B Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Effects of LINC00839 targeting miR-3666 on proliferation, migration and invasion of hepatocellular carcinoma cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Zhong Liu Za Zhi (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112152-20200222-00116"}], "href": "https://doi.org/10.3760/cma.j.cn112152-20200222-00116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34794216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34794216"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Smriti Mittal, Shrirang Inamdar, Jhankar Acharya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3666 inhibits development of hepatic steatosis by negatively regulating PPARγ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Cell Biol Lipids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2020.158777"}], "href": "https://doi.org/10.1016/j.bbalip.2020.158777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32755726"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32755726"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Huiping Tan, Chunlin Wu, Bo Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3666 serves as a tumor suppressor in ovarian carcinoma by down-regulating AK4 via targeting STAT3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-190538"}], "href": "https://doi.org/10.3233/CBM-190538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33361582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33361582"}]}]}]}
NCBI Gene ID 100500896
API
Download Associations
Predicted Functions View MIR3666's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3666's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3666's ARCHS4 Predicted Functions.

Functional Associations

MIR3666 has 284 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for MIR3666 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3666 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3666 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3666 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3666 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3666 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR3666 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3666 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3666 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3666 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3666 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.