{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts mention MIR3667 directly, the collective body of work addresses key mechanisms of mitochondrial uncoupling and energy‐metabolic regulation that offer a context in which one might consider microRNA involvement. Across these studies, proteins such as UCP1, UCP2, and particularly UCP3 are shown to modulate mitochondrial proton leak in “mild uncoupling” processes that attenuate reactive oxygen species production, promote fatty acid oxidation, adjust thermogenesis, and protect tissues against lipotoxicity and oxidative stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMany of the abstracts detail how various hormonal and stress signals—ranging from thyroid hormones and glucocorticoids to reactive oxygen species and fatty acids—regulate uncoupling protein gene expression via transcription factors such as PPARs, Nrf2, and ATF-1. These regulatory cascades adjust mitochondrial bioenergetics in diverse contexts including exercise adaptation, cold exposure, and high-fat feeding."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "12"}]}, {"type": "t", "text": " These studies not only emphasize the dynamic control of energy efficiency and oxidative balance but also suggest multiple levels where post-transcriptional regulation might contribute.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGiven that microRNAs are known to fine-tune gene expression, it is plausible to hypothesize that MIR3667—if operative in these contexts—could interface with such signaling networks by targeting transcripts of uncoupling proteins or the regulatory factors that modulate their expression. In doing so, MIR3667 might influence processes such as thermogenesis in brown adipose tissue, protection against ischemia-reperfusion injury in the heart, and the metabolic adaptations during exercise or nutrient excess, as detailed in the literature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "36"}, {"type": "fg_f", "ref": "31"}, {"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karim S Echtay, Damien Roussel, Julie St-Pierre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Superoxide activates mitochondrial uncoupling proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/415096a"}], "href": "https://doi.org/10.1038/415096a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11780125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11780125"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "N A Curtin, J C Clapham, C J Barclay "}, {"type": "b", "children": [{"type": "t", "text": "Excess recovery heat production by isolated muscles from mice overexpressing uncoupling protein-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2002.021964"}], "href": "https://doi.org/10.1113/jphysiol.2002.021964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12096064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12096064"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Martin D Brand, Reinald Pamplona, Manuel Portero-Otín, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20021077"}], "href": "https://doi.org/10.1042/BJ20021077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12193161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12193161"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Edward M Mills, Matthew L Banks, Jon E Sprague, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacology: uncoupling the agony from ecstasy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/426403a"}], "href": "https://doi.org/10.1038/426403a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14647371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14647371"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "C Son, K Hosoda, K Ishihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-003-1272-8"}], "href": "https://doi.org/10.1007/s00125-003-1272-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14673524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14673524"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Seung Hun Cha, Zhiyuan Hu, M Daniel Lane "}, {"type": "b", "children": [{"type": "t", "text": "Long-term effects of a fatty acid synthase inhibitor on obese mice: food intake, hypothalamic neuropeptides, and UCP3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.03.026"}], "href": "https://doi.org/10.1016/j.bbrc.2004.03.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15063757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15063757"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "V Bezaire, L L Spriet, S Campbell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.04-2765fje"}], "href": "https://doi.org/10.1096/fj.04-2765fje"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15814607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15814607"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Darren A Talbot, Martin D Brand "}, {"type": "b", "children": [{"type": "t", "text": "Uncoupling protein 3 protects aconitase against inactivation in isolated skeletal muscle mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbabio.2005.07.001"}], "href": "https://doi.org/10.1016/j.bbabio.2005.07.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16084485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16084485"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Andrew J Murray, Marcello Panagia, David Hauton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/diabetes.54.12.3496"}], "href": "https://doi.org/10.2337/diabetes.54.12.3496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16306367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16306367"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Joris Hoeks, Matthijs K C Hesselink, Wim Sluiter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of high-fat feeding on intramuscular lipid and lipid peroxidation levels in UCP3-ablated mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2006.01.059"}], "href": "https://doi.org/10.1016/j.febslet.2006.01.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16455084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16455084"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Cheol Soo Choi, Jonathan J Fillmore, Jason K Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI13579"}], "href": "https://doi.org/10.1172/JCI13579"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17571165"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17571165"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ethan J Anderson, Hanae Yamazaki, P Darrell Neufer "}, {"type": "b", "children": [{"type": "t", "text": "Induction of endogenous uncoupling protein 3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706129200"}], "href": "https://doi.org/10.1074/jbc.M706129200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17761668"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17761668"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Erin L Seifert, Véronic Bézaire, Carmen Estey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M803871200"}], "href": "https://doi.org/10.1074/jbc.M803871200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18628202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18628202"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sheila R Costford, Shehla N Chaudhry, Sean A Crawford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-term high-fat feeding induces greater fat storage in mice lacking UCP3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00779.2007"}], "href": "https://doi.org/10.1152/ajpendo.00779.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18713955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18713955"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Miranda Nabben, Joris Hoeks, Jacob J Briedé, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2008.11.016"}], "href": "https://doi.org/10.1016/j.febslet.2008.11.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19041310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19041310"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Esther Barreiro, Cèlia Garcia-Martínez, Sandra Mas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UCP3 overexpression neutralizes oxidative stress rather than nitrosative stress in mouse myotubes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2008.12.023"}], "href": "https://doi.org/10.1016/j.febslet.2008.12.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19101552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19101552"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kari E Wong, Frances L Szeto, Wenshuo Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.90763.2008"}], "href": "https://doi.org/10.1152/ajpendo.90763.2008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19176352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19176352"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Vian Azzu, Shona A Mookerjee, Martin D Brand "}, {"type": "b", "children": [{"type": "t", "text": "Rapid turnover of mitochondrial uncoupling protein 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20091321"}], "href": "https://doi.org/10.1042/BJ20091321"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19954423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19954423"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Junko Nishimura, Takayuki Masaki, Mie Arakawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Isoleucine prevents the accumulation of tissue triglycerides and upregulates the expression of PPARalpha and uncoupling protein in diet-induced obese mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nutr (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3945/jn.109.108977"}], "href": "https://doi.org/10.3945/jn.109.108977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20089773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20089773"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Irina G Shabalina, Joris Hoeks, Tatiana V Kramarova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbabio.2010.02.033"}], "href": "https://doi.org/10.1016/j.bbabio.2010.02.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20227385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20227385"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Assunta Lombardi, Rosa Anna Busiello, Laura Napolitano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UCP3 translocates lipid hydroperoxide and mediates lipid hydroperoxide-dependent mitochondrial uncoupling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.102699"}], "href": "https://doi.org/10.1074/jbc.M110.102699"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20363757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20363757"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Laurence J Toime, Martin D Brand "}, {"type": "b", "children": [{"type": "t", "text": "Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2010.05.010"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2010.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20493945"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20493945"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ryan J Mailloux, Erin L Seifert, Frédéric Bouillaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glutathionylation acts as a control switch for uncoupling proteins UCP2 and UCP3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.240242"}], "href": "https://doi.org/10.1074/jbc.M111.240242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21515686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21515686"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Miranda Nabben, Irina G Shabalina, Esther Moonen-Kornips, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbabio.2011.04.003"}], "href": "https://doi.org/10.1016/j.bbabio.2011.04.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21565164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21565164"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Michael Huntgeburth, Klaus Tiemann, Robert Shahverdyan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0026628"}], "href": "https://doi.org/10.1371/journal.pone.0026628"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22125598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22125598"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ryan J Mailloux, Jian Ying Xuan, Brittany Beauchamp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glutaredoxin-2 is required to control proton leak through uncoupling protein-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.442905"}], "href": "https://doi.org/10.1074/jbc.M112.442905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23335511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23335511"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Cevher Ozcan, Monica Palmeri, Tamas L Horvath, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Heart Circ Physiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpheart.00592.2012"}], "href": "https://doi.org/10.1152/ajpheart.00592.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23457013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23457013"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Andrea Anedda, Elia López-Bernardo, Bárbara Acosta-Iborra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2013.04.007"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2013.04.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23597505"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23597505"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Cinzia Perrino, Gabriele G Schiattarella, Anna Sannino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.113.000086"}], "href": "https://doi.org/10.1161/JAHA.113.000086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23688674"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23688674"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Natasha H Banke, E Douglas Lewandowski "}, {"type": "b", "children": [{"type": "t", "text": "Impaired cytosolic NADH shuttling and elevated UCP3 contribute to inefficient citric acid cycle flux support of postischemic cardiac work in diabetic hearts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2014.10.015"}], "href": "https://doi.org/10.1016/j.yjmcc.2014.10.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25450611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25450611"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Sara M Nowinski, Ashley Solmonson, Joyce E Rundhaug, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms9137"}], "href": "https://doi.org/10.1038/ncomms9137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26310111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26310111"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Karolina E Hilse, Anastasia V Kalinovich, Anne Rupprecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbabio.2015.10.011"}], "href": "https://doi.org/10.1016/j.bbabio.2015.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26518386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26518386"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Yu Kitaoka, Kohei Takeda, Yuki Tamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lactate administration increases mRNA expression of PGC-1α and UCP3 in mouse skeletal muscle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Appl Physiol Nutr Metab (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1139/apnm-2016-0016"}], "href": "https://doi.org/10.1139/apnm-2016-0016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27218871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27218871"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Christopher L Riley, Christine Dao, M Alexander Kenaston, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/JP272971"}], "href": "https://doi.org/10.1113/JP272971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27647490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27647490"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Keiko Higuchi, Takayuki Masaki, Koro Gotoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2006-1270"}], "href": "https://doi.org/10.1210/en.2006-1270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17347313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17347313"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Dawn J Mazzatti, Melissa A Smith, Radu C Oita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Muscle unloading-induced metabolic remodeling is associated with acute alterations in PPARdelta and UCP-3 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Genomics (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/physiolgenomics.00281.2007"}], "href": "https://doi.org/10.1152/physiolgenomics.00281.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18445701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18445701"}]}]}]}