{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided abstracts reveals an extensive body of work detailing the role of epigenetic regulators—most notably the histone H3 lysine 9 methyltransferase SETDB1 (also known as ESET)—in establishing repressive chromatin environments, silencing endogenous retroviruses, and controlling gene expression during embryogenesis, development, neural differentiation, immune cell function, and even tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMany of these studies further dissect how SETDB1 cooperates with cofactors and chromatin‐associated proteins—including KAP1, members of the Polycomb group complexes, and other chromatin modifiers—to deposit the H3K9me3 mark that represses aberrant transcription from retroelements and inappropriate lineage‐specific genes. These repressive mechanisms are highlighted across various cellular contexts such as embryonic stem cells, neural progenitors, germline cells, and somatic and tumorous tissues; they ensure genome stability and proper development through dynamic regulation of chromatin structure."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, however, none of the abstracts provide any direct reference to, or description of, MIR3668. While the collective findings underscore the critical functions of SETDB1/ESET and its associated repressive chromatin mechanisms, they do not mention or assign any role to MIR3668. Thus, based solely on the supplied literature, the function of MIR3668 remains undetermined, and further dedicated research will be necessary to elucidate whether MIR3668 participates in or modulates these epigenetic pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michael L Blackburn, Howard A Chansky, Anna Zielinska-Kwiatkowska, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0606373103"}], "href": "https://doi.org/10.1073/pnas.0606373103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17142323"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17142323"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alejandra Loyola, Hideaki Tagami, Tiziana Bonaldi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2009.90"}], "href": "https://doi.org/10.1038/embor.2009.90"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19498464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19498464"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Steve Bilodeau, Michael H Kagey, Garrett M Frampton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1837309"}], "href": "https://doi.org/10.1101/gad.1837309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19884255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19884255"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Felix Lohmann, Joseph Loureiro, Hui Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.278"}], "href": "https://doi.org/10.1002/stem.278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20014010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20014010"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Toshiyuki Matsui, Danny Leung, Hiroki Miyashita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08858"}], "href": "https://doi.org/10.1038/nature08858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20164836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20164836"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Mohammad M Karimi, Preeti Goyal, Irina A Maksakova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA methylation and SETDB1/H3K9me3 regulate predominantly distinct sets of genes, retroelements, and chimeric transcripts in mESCs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2011.04.004"}], "href": "https://doi.org/10.1016/j.stem.2011.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21624812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21624812"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sunwha Cho, Jung Sun Park, Yong-Kook Kang "}, {"type": "b", "children": [{"type": "t", "text": "Dual functions of histone-lysine N-methyltransferase Setdb1 protein at promyelocytic leukemia-nuclear body (PML-NB): maintaining PML-NB structure and regulating the expression of its associated genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.248534"}], "href": "https://doi.org/10.1074/jbc.M111.248534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21921037"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21921037"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Siok-Lay Tan, Miyuki Nishi, Toshiyuki Ohtsuka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.082198"}], "href": "https://doi.org/10.1242/dev.082198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22991445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22991445"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Helen M Rowe, Marc Friedli, Sandra Offner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.087585"}], "href": "https://doi.org/10.1242/dev.087585"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23293284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23293284"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yohei Kera, Yasutake Katoh, Mineto Ohta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.429738"}], "href": "https://doi.org/10.1074/jbc.M112.429738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23539621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23539621"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Liu Yang, Kevin A Lawson, Colin J Teteak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ESET histone methyltransferase is essential to hypertrophic differentiation of growth plate chondrocytes and formation of epiphyseal plates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2013.04.031"}], "href": "https://doi.org/10.1016/j.ydbio.2013.04.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23652029"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23652029"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sunwha Cho, Jung Sun Park, Yong-Kook Kang "}, {"type": "b", "children": [{"type": "t", "text": "Regulated nuclear entry of over-expressed Setdb1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/gtc.12068"}], "href": "https://doi.org/10.1111/gtc.12068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23782009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23782009"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kevin A Lawson, Colin J Teteak, Jidi Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ESET histone methyltransferase regulates osteoblastic differentiation of mesenchymal stem cells during postnatal bone development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2013.10.028"}], "href": "https://doi.org/10.1016/j.febslet.2013.10.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24188826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24188826"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Danny Leung, Tingting Du, Ulrich Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1322273111"}], "href": "https://doi.org/10.1073/pnas.1322273111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24757056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24757056"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "J An, X Zhang, J Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.171"}], "href": "https://doi.org/10.1038/cddis.2014.171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24763053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24763053"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sheng Liu, Julie Brind'Amour, Mohammad M Karimi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.244848.114"}], "href": "https://doi.org/10.1101/gad.244848.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25228647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25228647"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Peter J Thompson, Vered Dulberg, Kyung-Mee Moon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hnRNP K coordinates transcriptional silencing by SETDB1 in embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1004933"}], "href": "https://doi.org/10.1371/journal.pgen.1004933"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25611934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25611934"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Patrick L Collins, Katherine E Kyle, Takeshi Egawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1422187112"}], "href": "https://doi.org/10.1073/pnas.1422187112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26100872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26100872"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Qi Fei, Xiaoqin Yang, Hua Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gr.177576.114"}], "href": "https://doi.org/10.1101/gr.177576.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26160163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26160163"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jafar Sharif, Takaho A Endo, Manabu Nakayama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2016.03.013"}], "href": "https://doi.org/10.1016/j.stem.2016.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27151458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27151458"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Shuhei Koide, Motohiko Oshima, Keiyo Takubo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2016-01-694810"}], "href": "https://doi.org/10.1182/blood-2016-01-694810"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27301860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27301860"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Angeline Eymery, Zichuan Liu, Evgeniy A Ozonov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryos."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.132746"}], "href": "https://doi.org/10.1242/dev.132746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27317807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27317807"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Rumi Hachiya, Takuya Shiihashi, Ibuki Shirakawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep28845"}], "href": "https://doi.org/10.1038/srep28845"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27349785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27349785"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Shoichi Takikita, Ryunosuke Muro, Toshiyuki Takai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Histone Methyltransferase ESET Is Critical for T Cell Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1502486"}], "href": "https://doi.org/10.4049/jimmunol.1502486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27511731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27511731"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Tiantian Liu, Xiaoxu Chen, Tianjiao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gene Regul Mech (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2017.08.009"}], "href": "https://doi.org/10.1016/j.bbagrm.2017.08.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28890329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28890329"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Quan Zheng, Ying Cao, Yalan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jmcb/mjx055"}], "href": "https://doi.org/10.1093/jmcb/mjx055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29272473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29272473"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Özgen Deniz, Lorenzo de la Rica, Kevin C L Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genome Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13059-017-1376-y"}], "href": "https://doi.org/10.1186/s13059-017-1376-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29351814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29351814"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Takayuki Hirota, Paul Blakeley, Mahesh N Sangrithi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2018.10.004"}], "href": "https://doi.org/10.1016/j.devcel.2018.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30393076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30393076"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Véronique Adoue, Bénédicte Binet, Agathe Malbec, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Histone Methyltransferase SETDB1 Controls T Helper Cell Lineage Integrity by Repressing Endogenous Retroviruses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2019.01.003"}], "href": "https://doi.org/10.1016/j.immuni.2019.01.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30737147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30737147"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Ruicong Wang, Hongda Li, Jianfeng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gut stem cell necroptosis by genome instability triggers bowel inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-020-2127-x"}], "href": "https://doi.org/10.1038/s41586-020-2127-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32296174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32296174"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Satoshi Ogawa, Akihisa Fukuda, Yoshihide Matsumoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2020.04.047"}], "href": "https://doi.org/10.1053/j.gastro.2020.04.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32360551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32360551"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Lea Južnić, Kenneth Peuker, Anne Strigli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gutjnl-2020-321339"}], "href": "https://doi.org/10.1136/gutjnl-2020-321339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32503845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32503845"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Shang-Min Zhang, Wesley L Cai, Xiaoni Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KDM5B promotes immune evasion by recruiting SETDB1 to silence retroelements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-021-03994-2"}], "href": "https://doi.org/10.1038/s41586-021-03994-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34671158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34671158"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Kentaro Mochizuki, Jafar Sharif, Kenjiro Shirane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-27345-x"}], "href": "https://doi.org/10.1038/s41467-021-27345-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34857746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34857746"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Amandine Barral, Gabrielle Pozo, Lucas Ducrot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2021.12.037"}], "href": "https://doi.org/10.1016/j.molcel.2021.12.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35081363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35081363"}]}]}]}