{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nEMILIN2 is a multifunctional extracellular matrix glycoprotein that plays key roles in maintaining tissue microenvironments and regulating cellular functions. Structurally, it contains an N‑terminal EMI domain and a C‑terminal gC1q domain that mediate its assembly into multimeric complexes – both through homotypic and heterotypic interactions with EMILIN1 – thereby contributing to the integrity of basement membranes. In the cochlea, EMILIN2 is a major component of the basilar membrane where it likely contributes to its assembly and elastic properties, while in the bone marrow stroma its abundant deposition suggests an important role in modulating the hematopoietic niche. Moreover, studies in animal models indicate that EMILIN2 is critical for proper platelet function, influencing aggregation, clot retraction, and overall thrombus stability, which highlights its contribution to hemostasis and thrombosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its structural functions, EMILIN2 exerts a powerful influence on vascular biology. By directly binding to the epidermal growth factor receptor (EGFR), it enhances the production of proangiogenic cytokines such as interleukin‑8, thereby promoting endothelial cell proliferation and migration that are essential for angiogenesis. Furthermore, EMILIN2 facilitates pericyte recruitment and vascular stabilization by serving as an adhesion substrate through its interaction with integrins, and by triggering the synthesis of pericyte‑attracting factors like PDGF‑BB and HB‑EGF. These actions not only enhance vessel maturation and perfusion but also improve drug delivery and chemotherapeutic efficacy in tumor models."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lori L Amma, Richard Goodyear, Jonathan S Faris, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2014.10.001"}], "href": "https://doi.org/10.1016/j.matbio.2014.10.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25445627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25445627"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Menggui Huang, Devaraja Sannaningaiah, Nan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EMILIN2 regulates platelet activation, thrombus formation, and clot retraction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0115284"}], "href": "https://doi.org/10.1371/journal.pone.0115284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25658937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25658937"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alice Paulitti, Eva Andreuzzi, Dario Bizzotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-017-0107-x"}], "href": "https://doi.org/10.1038/s41388-017-0107-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29483644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29483644"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Francesco Da Ros, Luca Persano, Dario Bizzotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Emilin-2 is a component of bone marrow extracellular matrix regulating mesenchymal stem cell differentiation and hematopoietic progenitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res Ther (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13287-021-02674-2"}], "href": "https://doi.org/10.1186/s13287-021-02674-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35012633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35012633"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Albina Fejza, Lucrezia Camicia, Greta Carobolante, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Emilin2 fosters vascular stability by promoting pericyte recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2023.08.002"}], "href": "https://doi.org/10.1016/j.matbio.2023.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37579864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37579864"}]}]}]}