{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-3677-3p exhibits context‐dependent roles in tumor biology. In human osteosarcoma cells, miR-3677 directly binds to SphK1 mRNA, and its overexpression suppresses cell growth, proliferation, and migration, whereas its inhibition augments these processes—indicating that in this context miR-3677 acts as a tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma (HCC), however, miR-3677-3p is frequently upregulated and associates with poor clinical outcomes. Studies have demonstrated that miR-3677-3p promotes oncogenic behaviors through the direct suppression of tumor suppressor molecules. For example, one study showed that miR-3677-3p downregulates SIRT5, enhancing proliferation, migration, and invasion in HCC cells, particularly under hypoxic conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, another investigation reported that by directly targeting the 3′ untranslated region of GSK3β, miR-3677-3p effectively inhibited its expression and thereby facilitated tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, in hepatitis B virus–associated HCC, miR-3677-3p contributes to both tumor progression and sorafenib resistance through targeting FBXO31—which normally promotes the ubiquitylation and degradation of the oncogenic transcription factor FOXM1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn cervical cancer, the oncogenic potential of miR-3677-3p is further highlighted by its interaction with non-coding RNAs. Specifically, the long non-coding RNA TRAF3IP2-AS1 acts as a sponge for miR-3677-3p, thereby mitigating its ability to promote cell proliferation, migration, and invasion. This modulatory mechanism not only underscores the functional relevance of miR-3677-3p in tumor progression but also points to its potential utility as a diagnostic biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chen Yao, Jian-Wei Ruan, Yun-Rong Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The therapeutic value of the SphK1-targeting microRNA-3677 in human osteosarcoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102961"}], "href": "https://doi.org/10.18632/aging.102961"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32203055"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32203055"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bowen Yao, Yazhao Li, Yongshen Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced miR-3677-3p promotes the proliferation, migration and invasion of hepatocellular carcinoma cells by suppressing SIRT5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.15503"}], "href": "https://doi.org/10.1111/jcmm.15503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32596968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32596968"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yanfei Li, Yajie Zhou, Linlin Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3677-3p promotes hepatocellular carcinoma progression via inhibiting GSK3β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmaa125"}], "href": "https://doi.org/10.1093/abbs/gmaa125"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33200777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33200777"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hengzheng He, Jian Zhou, Fahui Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3677-3p promotes development and sorafenib resistance of hepatitis B-related hepatocellular carcinoma by inhibiting FOXM1 ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-023-00945-z"}], "href": "https://doi.org/10.1007/s13577-023-00945-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37402927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37402927"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chuncui Luo, Xixia Pang "}, {"type": "b", "children": [{"type": "t", "text": "IncRNA TRAF3IP2-AS1 Restrains Cervical Cancer Progression by Sponging miR-3677-3p and Acts As a Diagnostic Marker in Cervical Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Crit Rev Eukaryot Gene Expr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/CritRevEukaryotGeneExpr.2022044035"}], "href": "https://doi.org/10.1615/CritRevEukaryotGeneExpr.2022044035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36374810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36374810"}]}]}]}