{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have implicated members of the MIR3680 gene family in the regulation of skeletal homeostasis. In patients with chronic kidney disease–mineral and bone disorder (CKD-MBD), miR-3680-5p expression was found to be significantly associated with parathyroid hormone levels through modulation of the ubiquitin proteolysis pathway, suggesting a potential role in the degradation of parathyroid hormone and its related proteins. Similarly, emerging evidence in osteoarthritis (OA) research points to a role for miR-3680-3p in the regulation of joint tissue homeostasis and disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of CKD-MBD, patients undergoing peritoneal dialysis were observed to exhibit differential expression of miR-3680-5p when stratified by parathyroid hormone levels. Bioinformatic predictions identified several ubiquitin-specific proteases—USP6, USP32, USP46—and DLT as targets, suggesting that miR-3680-5p may influence the ubiquitin proteolysis pathway, thereby modulating the degradation of parathyroid hormone and contributing to skeletal alterations seen in CKD-MBD."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn osteoarthritis, the focus has shifted toward miR-3680-3p, where preliminary investigations seek to elucidate its role in knee joint degeneration and cartilage metabolism. Although the precise molecular mechanisms remain under exploration, this miRNA is emerging as a promising candidate in understanding and potentially modulating OA progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sohyun Jeong, Jung Mi Oh, Kook-Hwan Oh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differentially expressed miR-3680-5p is associated with parathyroid hormone regulation in peritoneal dialysis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0170535"}], "href": "https://doi.org/10.1371/journal.pone.0170535"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28152049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28152049"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanping Xie, Jianwei Li, Yanhui Suo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-3680-3p inhibits the progression of osteoarthritis via targeting OGG1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Gerontol Geriatr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.archger.2022.104626"}], "href": "https://doi.org/10.1016/j.archger.2022.104626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35092863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35092863"}]}]}]}