{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent findings indicate that the MIR3680-2 locus—giving rise to the mature microRNA miR-3680-3p—may contribute to the progression of osteoarthritis by modulating key regulatory networks involved in cartilage homeostasis and joint inflammation. In particular, investigation into osteoarthritic tissues suggests that miR-3680-3p influences the expression of genes and signaling cascades that underlie cartilage degradation and inflammatory responses, making it a potential biomarker and therapeutic target for mitigating disease progression. Although the precise molecular targets and downstream mechanisms remain to be fully characterized, this microRNA appears to function by fine‐tuning gene expression in affected joint tissues, thereby impacting the overall balance between anabolic and catabolic processes in articular cartilage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanping Xie, Jianwei Li, Yanhui Suo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of miR-3680-3p inhibits the progression of osteoarthritis via targeting OGG1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Gerontol Geriatr (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.archger.2022.104626"}], "href": "https://doi.org/10.1016/j.archger.2022.104626"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35092863"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35092863"}]}]}]}