{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nResearch across multiple cancer types has highlighted the complex regulatory roles of MIR3681. One study investigating miRNAs derived from transposable elements reported that hsa‐miR‐3681‑5p possesses a super-enhancer function by binding to the 3′ untranslated region (UTR) of SHISA7. In this context, miR‐3681‑5p and a variable number tandem repeat (VNTR) element share binding sites in the SHISA7 3′UTR, resulting in the repression of VNTR enhancer activity and altered target gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn glioblastoma, another study identified that the long non‐coding RNA HOXD‑AS2 is overexpressed and contributes to tumor aggressiveness by negatively regulating miR‑3681‑5p. This downregulation facilitates the upregulation of the oncogene MALT1, thereby promoting cell proliferation, migration, and invasion while inhibiting apoptosis. Conversely, restoring miR‑3681‑5p levels or knocking down MALT1 attenuates these malignant behaviors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, in lung adenocarcinoma, the lncRNA C2CD4D‑AS1 was found to be overexpressed and, under transcriptional activation by ETV4, contributes to cancer progression by sponging miR‑3681‑3p. The sequestration of miR‑3681‑3p leads to enhanced expression of NIMA‑related kinase 2 (NEK2), thereby facilitating increased cell proliferation, migration, invasion, and survival in lung adenocarcinoma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hee-Eun Lee, Sang-Je Park, Jae-Won Huh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enhancer Function of MicroRNA-3681 Derived from Long Terminal Repeats Represses the Activity of Variable Number Tandem Repeats in the 3' UTR of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SHISA7"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14348/molcells.2020.0058"}], "href": "https://doi.org/10.14348/molcells.2020.0058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32655015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32655015"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xingming Zhong, Yong Cai "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA (lncRNA) HOXD-AS2 promotes glioblastoma cell proliferation, migration and invasion by regulating the miR-3681-5p/MALT1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1977104"}], "href": "https://doi.org/10.1080/21655979.2021.1977104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34802389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34802389"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Binliang Wang, Yuanyuan Cai, Xiaobo Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.2005273"}], "href": "https://doi.org/10.1080/15384101.2021.2005273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34850664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34850664"}]}]}]}