MIR3682 Gene

HGNC Family Non-coding RNAs
Name microRNA 3682
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies in esophageal cancer have identified miR‑3682‑3p as an integral component of multi‐miRNA prognostic signatures. In these investigations, dysregulated expression of miR‑3682‑3p was linked to tumor progression via modulation of immune infiltration, the tumor microenvironment, and cellular stemness properties, suggesting that this microRNA may influence target gene networks that drive tumor aggressiveness. Moreover, its interplay with factors such as four and a half LIM domain protein 1 (FHL1) further implicates miR‑3682‑3p in the molecular mechanisms underlying esophageal tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn bladder cancer, miR‑3682‑3p has been shown to play a pivotal role in chemoresistance. Mechanistically, BMI1 overexpression leads to its recruitment—via interaction with p53—to the miR‑3682‑3p promoter, which in turn increases the monoubiquitination of histone H2A lysine 119. This epigenetic modification represses miR‑3682‑3p transcription, resulting in the derepression of genes such as ABCB1 that are key to drug efflux and the development of resistance against cisplatin and gemcitabine."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma, multiple investigations have assessed miR‑3682‑3p as a promising biomarker and functional regulator of disease progression. Its expression levels correlate with clinical parameters and prognosis, and emerging experimental data suggest that miR‑3682‑3p influences oncogenic pathways by modulating target gene expression. Furthermore, it appears to impact the tumor microenvironment, including immune cell infiltration and response to therapy, thereby reinforcing its potential utility not only as a diagnostic marker but also as a candidate for targeted therapeutic strategies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yue Zhao, Li Xu, Xinyu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel prognostic mRNA/miRNA signature for esophageal cancer and its immune landscape in cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12902"}], "href": "https://doi.org/10.1002/1878-0261.12902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33463006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33463006"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuxin Cai, Lingling Xia, Hangjia Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3682-3p promotes esophageal cancer progression by targeting FHL1 and activating the Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2024.111155"}], "href": "https://doi.org/10.1016/j.cellsig.2024.111155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38565413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38565413"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ming-Kun Chen, Jun-Hao Zhou, Peng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BMI1 activates P-glycoprotein via transcription repression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miR-3682-3p"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and enhances chemoresistance of bladder cancer cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203277"}], "href": "https://doi.org/10.18632/aging.203277"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34270461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34270461"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenyue Zhao, Xueping Liu "}, {"type": "b", "children": [{"type": "t", "text": "MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hepatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.aohep.2021.100570"}], "href": "https://doi.org/10.1016/j.aohep.2021.100570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34706275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34706275"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "S Liu, Y Wen, B Quan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[High expression of miR-3682-3p is an unfavorable prognostic factor of hepatocellular carcinoma]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2021.12.19"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2021.12.19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35012923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35012923"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yu Zhang, Hua Cai, Ming-Hao Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3682-3p Activated by c-Myc Aggravates the Migration and Stemness in Hepatocellular Carcinoma Cells by Regulating PTEN/PI3K/AKT/β-Catenin Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000527800"}], "href": "https://doi.org/10.1159/000527800"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36366818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36366818"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Pei-Dong Miao, Ying Li, Yu-Dong Jiang "}, {"type": "b", "children": [{"type": "t", "text": "Celestial Insights: Unraveling the Role of miR-3682-3p in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Gastroenterol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14309/ctg.0000000000000690"}], "href": "https://doi.org/10.14309/ctg.0000000000000690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38334941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38334941"}]}]}]}
Synonyms MIR-3682
NCBI Gene ID 100500850
API
Download Associations
Predicted Functions View MIR3682's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR3682's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR3682's ARCHS4 Predicted Functions.

Functional Associations

MIR3682 has 363 functional associations with biological entities spanning 3 categories (molecular profile, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR3682 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3682 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of MIR3682 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3682 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR3682 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR3682 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR3682 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of MIR3682 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR3682 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR3682 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of MIR3682 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR3682 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR3682 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.