{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR3686 (also referred to as mir3696) is demonstrated to function as a tumor suppressor in pancreatic cells through its direct targeting of polo-like kinase 1 (PLK1), a key protein implicated in tumorigenesis. Elevated expression of MIR3686 in the immortalized pancreas cell line HPDE6C7 is associated with a corresponding reduction in PLK1 levels relative to the pancreas carcinoma-derived PANC1 cell line. Functional assays reveal that restoration of MIR3686 in PANC1 cells not only downregulates PLK1 expression but also leads to inhibition of cell proliferation, induction of apoptosis, and suppression of both cell invasion and clonogenic survival. Conversely, inhibiting MIR3686 in HPDE6C7 cells enhances proliferative and invasive capabilities, reinforcing its role as a pivotal negative regulator of PLK1 and highlighting its potential as a therapeutic target in pancreatic cancer treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hong-Yi Jin, Xin-Guang Qiu, Bo Yang "}, {"type": "b", "children": [{"type": "t", "text": "The MicroRNA3686 Inhibits the Proliferation of Pancreas Carcinoma Cell Line by Targeting the Polo-Like Kinase 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/954870"}], "href": "https://doi.org/10.1155/2015/954870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26090465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26090465"}]}]}]}