{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nDiversin, also known as ANKRD6, is a pivotal regulator within the Wnt signaling pathways. It normally localizes to the centrosome in mammalian and Xenopus cells, and upon Wnt ligand stimulation its distribution shifts to the cell cortex, indicating that its subcellular localization is critical for proper beta‐catenin regulation and signaling specificity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in canonical Wnt signaling, Diversin/ANKRD6 functions as a key component in the regulation of planar cell polarity (PCP). It shares functional homology with the Drosophila Diego gene, as evidenced by its ability to rescue PCP defects and suppress overactive canonical Wnt signals; such findings underscore its importance in both signaling fidelity and tissue organization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDevelopmentally, the Ankrd6 gene exhibits a dynamic expression pattern within the mouse brain from embryonic stages through adulthood. Its expression in ventricular and migratory neuronal zones, and later in specific mature neuronal populations, suggests a role in neurodevelopment and possibly in mediating interactions with other signaling components, such as the Flamingo/Celsr proteins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther supporting its developmental impact, overexpression studies have demonstrated that Diversin enhances the proliferation of neuroblasts in the adult subventricular zone. This increase in neuroblast proliferation, alongside enhanced migration to the olfactory bulb, highlights a critical role for Diversin in adult neurogenesis and brain plasticity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDistinct from these developmental and signaling roles, miR-3692-3p has been recently reported to be overexpressed in the serum of non-small cell lung cancer patients. Although its expression profile and clinical utility in tumor tissues remain to be fully elucidated, this observation suggests that miR-3692-3p may have potential as a circulating biomarker in lung cancer, possibly reflecting alterations in underlying signaling pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Keiji Itoh, Andreas Jenny, Marek Mlodzik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Centrosomal localization of Diversin and its relevance to Wnt signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.057067"}], "href": "https://doi.org/10.1242/jcs.057067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19789178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19789178"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chonnettia Jones, Dong Qian, Sun Myoung Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2014.08.029"}], "href": "https://doi.org/10.1016/j.ydbio.2014.08.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25218921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25218921"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "F Tissir, I Bar, A M Goffinet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Dyn (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/dvdy.10126"}], "href": "https://doi.org/10.1002/dvdy.10126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12203740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12203740"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Makiko Ikeda, Yuki Hirota, Masanori Sakaguchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and proliferation-promoting role of Diversin in the neuronally committed precursor cells migrating in the adult mouse brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.516"}], "href": "https://doi.org/10.1002/stem.516"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20827749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20827749"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sachin Kumar, Vikas Gaur, Ishfaq A Mir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-3692-3p is overexpressed in lung tumors but may not serve as a prognostic biomarker in lung cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-022-08119-0"}], "href": "https://doi.org/10.1007/s11033-022-08119-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36414877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36414877"}]}]}]}