{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMiR-371b-5p, a member of the MIR371 family, has emerged as a potential serum biomarker in autoimmune pathologies. In systemic lupus erythematosus (SLE), for instance, elevated levels of miR-371b-5p in patient serum were significantly associated with disease activity, suggesting its utility in diagnosing and monitoring the disease’s clinical state. This upregulation in active SLE cases indicates that miR-371b-5p may serve as an accessible biomarker reflecting underlying immunological disturbances."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its diagnostic promise in SLE, computational studies have revealed that miR-371b-5p is intricately involved in the regulation of apoptosis. In silico analyses indicate that miR-371b-5p targets apoptosis-related genes such as CASP7, with identified single nucleotide polymorphisms (SNPs) in both the gene’s 3′UTR and the miR-371b-5p sequence itself potentially altering this regulation. These findings suggest that variations in miR-371b-5p interactions might affect programmed cell death pathways, thereby contributing to various pathophysiological conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of oncology, miR-371b-5p functions as a tumor suppressor, particularly in triple-negative breast cancer (TNBC). Studies have demonstrated that miR-371b-5p expression is diminished in TNBC cells, and its restoration significantly curbs cell growth, migration, and invasion. Mechanistic investigations revealed that miR-371b-5p directly targets cold shock domain-containing protein E1 (CSDE1), a regulator that in turn modulates RAC1 transcription. This suppression of the CSDE1/RAC1 axis underscores the microRNA’s capacity to interfere with oncogenic signaling pathways and highlights its potential as a prognostic biomarker in aggressive breast cancer subtypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Li Zeng, Jia-Li Wu, Li-Min Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum miRNA-371b-5p and miRNA-5100 act as biomarkers for systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clim.2018.10.004"}], "href": "https://doi.org/10.1016/j.clim.2018.10.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30304699"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30304699"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Muhammad Safdar, Sana Zaheer, Rozhgar A Khailany, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Biophys (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12013-020-00941-2"}], "href": "https://doi.org/10.1007/s12013-020-00941-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32951155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32951155"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yesol Kim, Je Yeong Ko, Soo-Been Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced miR-371b-5p expression drives tumor progression via CSDE1/RAC1 regulation in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-022-02326-6"}], "href": "https://doi.org/10.1038/s41388-022-02326-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35490208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35490208"}]}]}]}