{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the critical role of miR-374c-5p as a tumor suppressor in diverse cancers. In breast cancer, miR-374c-5p is expressed at low levels, and its upregulation has been shown to significantly inhibit cell proliferation, migration, and epithelial–mesenchymal transition (EMT), while promoting apoptosis. Mechanistically, miR-374c-5p interacts with and downregulates TAF7, which in turn modulates DEPDC1 expression, thereby suppressing tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n \nIn parallel, investigations in hepatocellular carcinoma (HCC) have demonstrated that a similar downregulation of miR-374c-5p is associated with poor patient prognosis and shorter survival. Enhancing its expression in HCC cell lines not only restrains proliferation, migration, and invasion, but also inhibits tumor growth in vivo. This effect is achieved through the direct targeting of the 3′‐untranslated region of PTTG1, which modulates EMT and malignant cell behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n \nCollectively, these findings from breast cancer and HCC studies indicate that miR-374c-5p plays a pivotal role in suppressing tumor development via distinct molecular pathways. Its dual functionality in regulating TAF7/DEPDC1 and PTTG1-mediated transcriptional and posttranscriptional events positions miR-374c-5p as a promising diagnostic marker and therapeutic target in the treatment of malignant tumors.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuai Hao, Wuguo Tian, Yi Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-374c-5p inhibits the development of breast cancer through TATA-box binding protein associated factor 7-mediated transcriptional regulation of DEP domain containing 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28803"}], "href": "https://doi.org/10.1002/jcb.28803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31162714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31162714"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gang Yang, Yongfu Xiog, Guan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑374c‑5p regulates PTTG1 and inhibits cell growth and metastasis in hepatocellular carcinoma by regulating epithelial‑mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2022.12664"}], "href": "https://doi.org/10.3892/mmr.2022.12664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35234260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35234260"}]}]}]}