{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma (HCC), miR-376a (also referred to as MIR376A2) functions as a tumor suppressor. Its expression is frequently down-regulated in HCC tissues and cell lines, and restoration of its levels inhibits cell proliferation while inducing apoptosis. Mechanistically, miR-376a directly targets p85α (PIK3R1), suggesting that its decreased expression may facilitate oncogenic signaling pathways that contribute to HCC development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn non‐small cell lung cancer (NSCLC), miR-376a-3p plays a similar suppressive role. Here, a circular RNA, circ-UBE2D2, acts as a molecular sponge for miR-376a-3p, reducing its availability and thereby indirectly promoting the expression of EIF4G2, an important factor in translation initiation. Consequently, diminished miR-376a-3p activity is associated with increased cell proliferation, migration, and invasion, while its overexpression leads to apoptosis. These findings extend the tumor-suppressive functions of miR-376a across cancer types by regulating key pathways involved in cell growth and survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yongxia Zheng, Lei Yin, Huan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2012.05.054"}], "href": "https://doi.org/10.1016/j.febslet.2012.05.054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22684007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22684007"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "JiChun Tong, JiaWei Lu, XiaoLiang Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4γ2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2027068"}], "href": "https://doi.org/10.1080/21655979.2022.2027068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35196197"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35196197"}]}]}]}