MIR376B Gene

HGNC Family Non-coding RNAs
Name microRNA 376b
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that the miR‑376b family, including its −3p and −5p isoforms, plays a critical role in maintaining cellular homeostasis. In breast and liver‐derived cells, miR‑376b directly targets ATG4C and BECN1, key proteins required for autophagy, thereby attenuating starvation‐ and rapamycin‑induced autophagic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, miR‑376b‑5p has been shown to repress angiogenesis in a cerebral ischemia model by inhibiting the HIF‑1α–mediated VEGFA/Notch1 signaling pathway, and in malignant glioma its −3p isoform suppresses cell proliferation, invasion, and vasculogenic mimicry via regulation of HOXD10 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn carcinomas, miR‑376b has emerged as an important modulator of tumor cell dynamics. In non‑small cell lung cancer, overexpression of miR‑376b‑3p reduces proliferation and induces apoptosis through direct targeting of Kruppel‑like factor 15 (KLF15), highlighting its tumor‑suppressive capacity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In addition, studies in hepatocellular carcinoma have demonstrated that the long non‑coding RNA LINC01980 acts as a molecular sponge for miR‑376b‑5p. This sequestration leads to enhanced expression of E2F5, promoting epithelial–mesenchymal transition and metastatic progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its impact on autophagy and tumorigenesis, the miR‑376b family is also implicated in immune regulation. MicroRNAs are now recognized as key regulators in autoimmune conditions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and miR‑376b has been specifically investigated in the context of thyroid‑associated ophthalmopathy, suggesting that its dysregulation may contribute to pathogenic immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gozde Korkmaz, Carlos le Sage, Kumsal Ayse Tekirdag, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.8.2.18351"}], "href": "https://doi.org/10.4161/auto.8.2.18351"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22248718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22248718"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ling-Juan Li, Qing Huang, Ning Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-376b-5p regulates angiogenesis in cerebral ischemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2014.2172"}], "href": "https://doi.org/10.3892/mmr.2014.2172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24789343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24789343"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J Jiang, S Wang, Q H Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Study on the expression of non-coding microRNA-376b-3p in serum exosomes of patients with malignant glioma and the mechanism of anti-angiogenesis]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Za Zhi (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112137-20200227-00482"}], "href": "https://doi.org/10.3760/cma.j.cn112137-20200227-00482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32486598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32486598"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "X-W Liu, C-C Zhang, T Zhang "}, {"type": "b", "children": [{"type": "t", "text": "MiR-376b-3p functions as a tumor suppressor by targeting KLF15 in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202009_23033"}], "href": "https://doi.org/10.26355/eurrev_202009_23033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33015790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33015790"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jiaqi Sheng, Yiming Luo, Enjun Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC01980 induced by TGF-beta promotes hepatocellular carcinoma metastasis via miR-376b-5p/E2F5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2023.110923"}], "href": "https://doi.org/10.1016/j.cellsig.2023.110923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37827344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37827344"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rongjiao Liu, Xinran Ma, Lingyan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2011-2982"}], "href": "https://doi.org/10.1210/jc.2011-2982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22456620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22456620"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Rongjiao Liu, Zhengqin Ye, Qi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-376b is involved in the pathogenesis of thyroid-associated ophthalmopathy by regulating HAS2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12020-023-03382-y"}], "href": "https://doi.org/10.1007/s12020-023-03382-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37231239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37231239"}]}]}]}
Synonyms MIRN376B, MIR-376B
NCBI Gene ID 574435
API
Download Associations
Predicted Functions View MIR376B's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR376B's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR376B's ARCHS4 Predicted Functions.

Functional Associations

MIR376B has 291 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 12 datasets.

Click the + buttons to view associations for MIR376B from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR376B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR376B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR376B gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR376B gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR376B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR376B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR376B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR376B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR376B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR376B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR376B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR376B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.