{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR‐377 plays diverse non‐oncogenic roles in metabolic, inflammatory, and degenerative disorders. In diabetic nephropathy, for example, elevated miR‐377 expression in glomerular cells indirectly augments fibronectin accumulation by suppressing proteins that normally protect against oxidative stress, while, in hemin‐stimulated cells, miR‐377 (in concert with other miRNAs) downregulates HO‐1 protein despite unchanged mRNA levels. In addition, miR‐377 has been implicated in skin fibroblast senescence, where its upregulation—through targeting DNMT1 and affecting p53 expression—promotes aging features in human skin. miR‐377 is also dysregulated in diabetic retinopathy, intensifying angiogenesis and inflammation by directly downregulating SIRT1, and its levels in blood or serum—as assessed in diabetic nephropathy, systemic lupus erythematosus, and diabetic macular edema—have been proposed as promising non‐invasive biomarkers. Moreover, altered miR‐377 expression affects placental cell growth by modulating key growth factor pathways, influences intervertebral disc homeostasis by regulating extracellular matrix‐degrading enzymes, and has been shown to modulate adipogenic differentiation of mesenchymal stem cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncological settings miR‐377 exerts context‐dependent functions that can be either tumor‐suppressive or oncogenic. In several malignancies—including prostate, esophageal squamous, renal, cervical, hepatocellular, non‐small cell lung, glioblastoma, and neuroblastoma cancers—miR‐377 is frequently downregulated; its re‐expression limits cancer cell proliferation, migration, invasion, and epithelial–mesenchymal transition by directly targeting oncogenic proteins such as FZD4, ETS1, CDK6, ZEB2, HOXC6, EZH2, and CBX3. Conversely, in other cancers such as certain colorectal and gastric carcinomas, miR‐377–3p is upregulated and appears to promote tumorigenesis through activation of NF‐κB signaling and by downregulating tumor suppressors including p53, PTEN, and TIMP1. Moreover, miR‐377 influences therapeutic responses in lung adenocarcinoma by modulating CASP1 and is subject to regulation by competing endogenous RNAs—including lncRNAs (e.g. NEAT1, SNHG5) and circular RNAs—which sponge miR‐377 to de‐repress their target oncogenes. Collectively, these studies underscore that miR‐377’s role in cancer is highly context‐dependent, contributing either to oncogenic progression or suppression depending on the tumor type and microenvironment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "43"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiang Wang, Youli Wang, Andrew W Minto, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MiR-377 inhibits the proliferation of pancreatic cancer by targeting Pim-3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-016-5295-4"}], "href": "https://doi.org/10.1007/s13277-016-5295-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27638830"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27638830"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wei-Ying Liu, Zhen Yang, Qi Sun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA regulation of mitogenic signaling networks in the human placenta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.587295"}], "href": "https://doi.org/10.1074/jbc.M114.587295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25077964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25077964"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Wen-Yuan Zhang, Qing-Hong Liu, Tie-Jun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20192779"}], "href": "https://doi.org/10.1042/BSR20192779"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31746333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31746333"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Rufen Yu, Limei Cai, Yingui Chi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR‑377 targets CUL4A and regulates metastatic capability in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2018.3540"}], "href": "https://doi.org/10.3892/ijmm.2018.3540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29512715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29512715"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "ZheXing Wang, LiMing Pan, HaiXiang Yu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circVAPA Promotes Cell Proliferation in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Gene Ther Clin Dev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/humc.2019.079"}], "href": "https://doi.org/10.1089/humc.2019.079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31368365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31368365"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "X-Y Zhang, X-M Dong, F-P Wang "}, {"type": "b", "children": [{"type": "t", "text": "MiR-377-3p inhibits cell metastasis and epithelial-mesenchymal transition in cervical carcinoma through targeting SGK3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202005_21156"}], "href": "https://doi.org/10.26355/eurrev_202005_21156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32432732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32432732"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "H Yang, J F Guo, M L Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-377 predicts poor clinical outcome of gastric cancer and induces tumorigenesis by targeting multiple tumor-suppressor genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2015.3981"}], "href": "https://doi.org/10.3892/or.2015.3981"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25998046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25998046"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Liulin Tang, Bin Yang, Xiaolan Cao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-377-3p inhibits growth and invasion through sponging JAG1 in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13258-019-00822-w"}], "href": "https://doi.org/10.1007/s13258-019-00822-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31041680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31041680"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Feng Geng, Wen-Cong Jia, Tao Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-377 inhibits non-small-cell lung cancer through targeting AEG-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26823698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26823698"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Zhisheng He, Junjing Chen, Xiaoliang Chen, et al. 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