{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies indicate that MIR378B (commonly reported as miR‐378 or miR‐378b) plays multifaceted roles in cancer biology. In glioma, decreased expression of miR‐378 has been associated with aggressive tumor behavior and poorer overall survival, while its overexpression inhibited cell migration and invasion, suggesting that it acts as a tumor suppressor. Similarly, in non‐small‐cell lung cancer, altered levels of serum exosomal miR‐378 have been correlated with disease status and hold promise as early detection and prognostic biomarkers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its oncologic significance, MIR378B is implicated in the regulation of angiogenesis and tissue repair. In patients experiencing myocardial infarction, differential regulation of angio‐miRs – a group that includes miR‐378 – in mobilized bone marrow‐derived CD34⁺ progenitor cells suggests an important role in promoting neovascularization necessary for effective cardiac repair. Moreover, related miRNA variants, such as miR‐1378b studied in UVB‐exposed human dermal fibroblasts, underscore how microRNA‐mediated regulation of targets like SIRT6 can influence extracellular matrix remodeling and anti‐aging processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, emerging evidence from colorectal cancer research highlights a regulatory network in which MIR378B is a key mediator. Here, the long non‐coding RNA CDKN2B‑AS1 functions as a molecular sponge for miR‐378b, relieving suppression of its downstream target CAPRIN2 and consequently activating β‐catenin signaling. This interaction promotes tumor cell proliferation and migration, proposing the MIR378B/CAPRIN2/β‐catenin axis as a potential target for prognostic assessment and therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bing Li, Yilin Wang, Shiting Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of miR-378 correlates with tumor invasiveness and poor prognosis of patients with glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26261592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26261592"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yan Zhang, Hongjie Xu "}, {"type": "b", "children": [{"type": "t", "text": "Serum exosomal miR-378 upregulation is associated with poor prognosis in non-small-cell lung cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Lab Anal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcla.23237"}], "href": "https://doi.org/10.1002/jcla.23237"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32061007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32061007"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christian Templin, Julia Volkmann, Maximilian Y Emmert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.116.308695"}], "href": "https://doi.org/10.1161/ATVBAHA.116.308695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28062497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28062497"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dahye Joo, Sungkwan An, Byung Gon Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑378b regulates α‑1‑type 1 collagen expression via sirtuin 6 interference."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7657"}], "href": "https://doi.org/10.3892/mmr.2017.7657"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28983623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28983623"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yu Zheng, Jintao Zeng, Haoyun Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated lncRNA Cyclin-dependent kinase inhibitor 2B antisense RNA 1 induces the proliferation and migration of colorectal cancer by miR-378b/CAPRIN2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1961656"}], "href": "https://doi.org/10.1080/21655979.2021.1961656"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34511033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34511033"}]}]}]}