{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMIR378C has emerged as a pivotal regulator involved in both oncologic and vascular contexts. In glioma, a related form of MIR378C is expressed at lower levels than in non‐neoplastic brain tissues, with its downregulation correlating with poorer overall survival and enhanced tumor cell migration and invasion, implicating a tumor‐suppressive function ([1]). In addition, the broad significance of miRNAs in vascular repair is evidenced by studies of mobilized bone marrow–derived CD34⁺ progenitor cells from myocardial infarction patients, in which differential regulation of angio‐miRs highlights their role in promoting neovascularization ([2]). Moreover, in lung adenocarcinoma, oncogenic PVT1 mediates the suppression of MIR378C, thereby relieving its inhibitory effect on SLC2A1 and facilitating cell proliferation, migration, and invasion ([3])."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pediatric malignancies such as Wilms tumor, MIR378C is similarly downregulated; its overexpression inhibits tumor growth and metastatic behavior via direct targeting of CAMKK2, reinforcing its tumor‐suppressive role ([4]). Furthermore, in the context of atherosclerosis, reduced MIR378C levels contribute to vascular smooth muscle cell phenotypic transition and promote LDL oxidation and foam cell formation by diminishing its repression of Samd1, whereas restoration of MIR378C is protective against lesion development ([5]). Collectively, these findings underscore the multifaceted functions of MIR378C as both a tumor suppressor and a modulator of vascular pathology—highlighting its potential as a promising therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bing Li, Yilin Wang, Shiting Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased expression of miR-378 correlates with tumor invasiveness and poor prognosis of patients with glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26261592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26261592"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christian Templin, Julia Volkmann, Maximilian Y Emmert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.116.308695"}], "href": "https://doi.org/10.1161/ATVBAHA.116.308695"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28062497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28062497"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongwei Xia, Zhiqiang Zhang, Jun Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA PVT1 promotes invasive growth of lung adenocarcinoma cells by targeting miR-378c to regulate SLC2A1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13577-020-00434-7"}], "href": "https://doi.org/10.1007/s13577-020-00434-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32960438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32960438"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Qiang Yu, Baijun Zheng, Xiang Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/abbs/gmab047"}], "href": "https://doi.org/10.1093/abbs/gmab047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33956079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33956079"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shengya Tian, Yang Cao, Jinliang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-378c-Samd1 circuit promotes phenotypic modulation of vascular smooth muscle cells and foam cells formation in atherosclerosis lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-89981-z"}], "href": "https://doi.org/10.1038/s41598-021-89981-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34006929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34006929"}]}]}]}