{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nIn oral squamous cell carcinoma, microRNA‐378g (miR‐378g) acts as a tumor suppressor by inhibiting malignant behaviors. In one study, the long non‐coding RNA HOXC13 antisense (HOXC13‐AS) was found to be upregulated and to promote oncogenic functions by sequestering miR‐378g, thereby releasing its repression on the neighboring gene HOXC13—a driver of cell proliferation, migration, and epithelial‐to‐mesenchymal transition (EMT)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn nasopharyngeal carcinoma, miR‐378g has been investigated for its potential role in modulating cell radiosensitivity and metastatic capacity, with preliminary work focusing on its regulation of Src homology region 2 domain‐containing phosphatase‐1 (SHP‐1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in the context of allergic rhinitis, miR‐378g is integrated into an immunoregulatory axis where the long non‐coding RNA JP X functions as a molecular sponge for miR‐378g. This interaction modulates the expression of chemokine CCL5 and, consequently, the balance between regulatory T cells (Treg) and T helper 17 (Th17) cells, thereby impacting the inflammatory milieu associated with the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditionally, while other studies have explored competing endogenous RNA (ceRNA) networks in oral squamous cell carcinoma—such as those mediated by FOXD2‐AS1—the direct involvement of miR‐378g in these networks remains to be elucidated. This highlights the need for further research to fully clarify the diverse regulatory roles of miR‐378g across different pathological contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wenlu Li, Qiuyu Zhu, Sanke Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HOXC13-AS accelerates cell proliferation and migration in oral squamous cell carcinoma via miR-378g/HOXC13 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.oraloncology.2020.104946"}], "href": "https://doi.org/10.1016/j.oraloncology.2020.104946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32763778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32763778"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ting Lin, Fangzheng Zhou, Haibo Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-378g enhanced radiosensitivity of NPC cells partially by targeting protein tyrosine phosphatase SHP-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Radiat Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/09553002.2015.1096028"}], "href": "https://doi.org/10.3109/09553002.2015.1096028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26473472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26473472"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ziqi Chen, Xia Ke, Xiaoqiang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA JPX contributes to Treg/Th17 imbalance in allergic rhinitis "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " targeting the miR-378g/CCL5 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunopharmacol Immunotoxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/08923973.2022.2055566"}], "href": "https://doi.org/10.1080/08923973.2022.2055566"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35387544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35387544"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shaoyong Guo, Bixia Huang, Zhisong You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXD2-AS1 promotes malignant cell behavior in oral squamous cell carcinoma via the miR-378 g/CRABP2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Oral Health (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12903-024-04388-2"}], "href": "https://doi.org/10.1186/s12903-024-04388-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38807101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38807101"}]}]}]}