MIR380 Gene

HGNC Family Non-coding RNAs
Name microRNA 380
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nmiR-380 has emerged as a critical regulator in various pathophysiological contexts. In several cancers, notably neuroblastoma and IDH1-mutant gliomas, the miR-380-5p isoform suppresses p53 expression by binding to a conserved sequence in the p53 3′ untranslated region. This repression of a key tumor suppressor promotes cell survival under stress, inhibits oncogene‐induced senescence, and facilitates tumorigenic transformation via cooperation with oncogenic signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDistinct from its role in modulating p53, the miR-380-3p isoform has been implicated in non-cancer conditions as well as additional cancer types. In systemic lupus erythematosus, altered plasma levels of miR-380-3p serve as a potential diagnostic biomarker for lupus nephritis, indicating its promise in non-invasive detection of renal involvement. Moreover, in pancreatic cancer, miR-380-3p is upregulated and enriched with m6A modifications, targeting the 3′UTR of PTEN to activate the downstream Akt signaling pathway and thereby promoting cell proliferation, epithelial–mesenchymal transition, and tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of acute kidney injury associated with sepsis, miR-380-3p is also elevated. Here, it negatively regulates RAP1B expression, which in turn exacerbates inflammatory responses and oxidative stress through activation of the NF-κB pathway. Downregulation of miR-380-3p in sepsis models ameliorates cellular injury and apoptosis, underscoring its potential as a therapeutic target in septic acute kidney injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nWhile the molecular underpinnings of chronic obstructive pulmonary disease are under intensive investigation, this work highlights the broader significance of miR-380 isoforms in modulating key signaling pathways across diverse pathological settings. Continued exploration of miR-380 function may reveal shared mechanistic themes that link oncogenesis, immune-mediated renal injury, and other complex diseases."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alexander Swarbrick, Susan L Woods, Alexander Shaw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2227"}], "href": "https://doi.org/10.1038/nm.2227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20871609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20871609"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bin Jiang, Wentao Zhao, Minggang Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA117.001385"}], "href": "https://doi.org/10.1074/jbc.RA117.001385"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29743236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29743236"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Elkin Navarro-Quiroz, Lisandro Pacheco-Lugo, Hernan Lorenzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0166202"}], "href": "https://doi.org/10.1371/journal.pone.0166202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27835701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27835701"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Zhijia Jiang, Xiaomeng Song, Yaqing Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N(6)-methyladenosine-mediated miR-380-3p maturation and upregulation promotes cancer aggressiveness in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2088497"}], "href": "https://doi.org/10.1080/21655979.2022.2088497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35758158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35758158"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jifang Liang, Bo Li, Yanmei Xia "}, {"type": "b", "children": [{"type": "t", "text": "MicroR-380-3p Reduces Sepsis-Induced Acute Kidney Injury via Regulating RAB1P to Restrain NF-κB Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tohoku J Exp Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1620/tjem.2023.J106"}], "href": "https://doi.org/10.1620/tjem.2023.J106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38220171"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38220171"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiujun Wu "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of miR-380 mitigates human bronchial epithelial cells injury to improve chronic obstructive pulmonary disease through targeting CHRNA4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Probes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcp.2019.101492"}], "href": "https://doi.org/10.1016/j.mcp.2019.101492"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31821848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31821848"}]}]}]}
Synonyms MIR380-3P, MIRN380, MIR-380, HSA-MIR-380
NCBI Gene ID 494329
API
Download Associations
Predicted Functions View MIR380's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR380's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR380's ARCHS4 Predicted Functions.

Functional Associations

MIR380 has 245 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for MIR380 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR380 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR380 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR380 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR380 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR380 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR380 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR380 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR380 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR380 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR380 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR380 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR380 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR380 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR380 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.