MIR384 Gene

HGNC Family Non-coding RNAs
Name microRNA 384
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that microRNA‐384 (miR‑384) plays diverse roles in regulating key cellular processes in both neurodegenerative disorders and a wide spectrum of cancers. In Alzheimer’s disease, for example, overexpression of miR‑384 suppresses both amyloid precursor protein (APP) and β‑site APP cleaving enzyme (BACE‑1), thereby reducing amyloid‑β production and suggesting its potential as a biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma (HCC), decreased levels of miR‑384 relieve inhibition of insulin receptor substrate 1 (IRS1) and, in a complementary study, pleiotrophin (PTN) whose increased expression activates STAT3 signaling; each of these mechanisms contributes to enhanced tumor proliferation and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn colorectal cancer, low miR‑384 expression permits the derepression of oncogenic factors such as KRAS and CDC42, promoting an invasive phenotype"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in renal cell carcinoma, re‐expression of miR‑384 impairs tumor invasion by directly targeting astrocyte elevated gene‑1 (AEG‑1)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In osteosarcoma, reduced miR‑384 levels correlate with increased tumor growth via upregulation of key factors such as SLBP"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and additional evidence suggests that miR‑384 may also modulate tumor progression through the MECP2/IGFBP3 regulatory axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In triple‑negative breast cancer, miR‑384 targets ACVR1, leading to suppression of the Wnt/β‑catenin pathway and consequent inhibition of cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, in non‑small cell lung cancer (NSCLC), miR‑384 downregulation results in increased expression of COL10A1, thereby enhancing cell proliferation and tumorigenicity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Its tumor‑suppressive role is also evident in nasopharyngeal and laryngeal carcinomas, where miR‑384—sequestered by the long non‑coding RNA TUG1 in nasopharyngeal cancer—antagonizes epithelial‑mesenchymal transition, and in laryngeal cancer where it directly targets WISP1 to inhibit cell proliferation and induce apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of neurodegeneration, studies in Parkinson’s disease models have demonstrated that upregulation of miR‑384‑5p exacerbates neurotoxicity by directly targeting Sirtuin 1 (SIRT1), a key modulator of endoplasmic reticulum stress and neuronal survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Collectively, these findings underscore miR‑384’s multifaceted function as a tumor suppressor and as a modulator of neurodegenerative pathways—findings that pinpoint miR‑384 as a promising target for therapeutic intervention as well as for diagnostic applications.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chen-Geng Liu, Jin-Ling Wang, Lei Li, et al. 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Synonyms HSA-MIR-384, MIRN384
NCBI Gene ID 494333
API
Download Associations
Predicted Functions View MIR384's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR384's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR384's ARCHS4 Predicted Functions.

Functional Associations

MIR384 has 190 functional associations with biological entities spanning 6 categories (molecular profile, disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 17 datasets.

Click the + buttons to view associations for MIR384 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR384 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR384 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of MIR384 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR384 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
CTD Gene-Disease Associations diseases associated with MIR384 gene/protein from the curated CTD Gene-Disease Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR384 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of MIR384 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of MIR384 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR384 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of MIR384 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR384 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of MIR384 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of MIR384 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR384 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of MIR384 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of MIR384 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at MIR384 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.